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Title: Essential functions of miR-125b in cancer
Authors: Peng, Boya
Theng, Poh Ying 
Le, Minh T. N. 
Keywords: biomarker
Issue Date: 17-Dec-2020
Publisher: Blackwell Publishing Ltd
Citation: Peng, Boya, Theng, Poh Ying, Le, Minh T. N. (2020-12-17). Essential functions of miR-125b in cancer. Cell Proliferation 54 (2) : e12913. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: MicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that silence target mRNAs, and compelling evidence suggests that they play an essential role in the pathogenesis of human diseases, especially cancer. miR-125b, which is the mammalian orthologue of the first discovered miRNA lin-4 in Caenorhabditis elegans, is one of the most important miRNAs that regulate various physiological and pathological processes. The role of miR-125b in many types of cancer has been well established, and so here we review the current knowledge of how miR-125b is deregulated in different types of cancer; its oncogenic and/or tumour-suppressive roles in tumourigenesis and cancer progression; and its regulation with regard to treatment response, all of which are underlined in multiple studies. The emerging information that elucidates the essential functions of miR-125b might help support its potentiality as a diagnostic and prognostic biomarker as well as an effective therapeutic tool against cancer. © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd
Source Title: Cell Proliferation
ISSN: 0960-7722
DOI: 10.1111/cpr.12913
Rights: Attribution 4.0 International
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