Please use this identifier to cite or link to this item: https://doi.org/10.1111/cpr.12913
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dc.titleEssential functions of miR-125b in cancer
dc.contributor.authorPeng, Boya
dc.contributor.authorTheng, Poh Ying
dc.contributor.authorLe, Minh T. N.
dc.date.accessioned2022-10-13T07:58:35Z
dc.date.available2022-10-13T07:58:35Z
dc.date.issued2020-12-17
dc.identifier.citationPeng, Boya, Theng, Poh Ying, Le, Minh T. N. (2020-12-17). Essential functions of miR-125b in cancer. Cell Proliferation 54 (2) : e12913. ScholarBank@NUS Repository. https://doi.org/10.1111/cpr.12913
dc.identifier.issn0960-7722
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/233282
dc.description.abstractMicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that silence target mRNAs, and compelling evidence suggests that they play an essential role in the pathogenesis of human diseases, especially cancer. miR-125b, which is the mammalian orthologue of the first discovered miRNA lin-4 in Caenorhabditis elegans, is one of the most important miRNAs that regulate various physiological and pathological processes. The role of miR-125b in many types of cancer has been well established, and so here we review the current knowledge of how miR-125b is deregulated in different types of cancer; its oncogenic and/or tumour-suppressive roles in tumourigenesis and cancer progression; and its regulation with regard to treatment response, all of which are underlined in multiple studies. The emerging information that elucidates the essential functions of miR-125b might help support its potentiality as a diagnostic and prognostic biomarker as well as an effective therapeutic tool against cancer. © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd
dc.publisherBlackwell Publishing Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectbiomarker
dc.subjectcancer
dc.subjectchemoresistance
dc.subjectmicroRNA
dc.subjectmiR-125b
dc.typeReview
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.1111/cpr.12913
dc.description.sourcetitleCell Proliferation
dc.description.volume54
dc.description.issue2
dc.description.pagee12913
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