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Title: Gut microbiome of indonesian adults associated with obesity and type 2 diabetes: A cross-sectional study in an asian city, yogyakarta
Authors: Therdtatha, Phatthanaphong
Song, Yayi
Tanaka, Masaru
Mariyatun, Mariyatun
Almunifah, Maisaroh
Manurung, Nancy Eka Putri
Indriarsih, Siska
Lu, Yi
Nagata, Koji
Fukami, Katsuya
Ikeda, Tetsuo
Lee, Yuan-Kun 
Rahayu, Endang Sutriswati
Nakayama, Jiro
Keywords: Bile acids
Dietary habits
Gut microbiome
Type 2 diabetes
Issue Date: 22-Apr-2021
Publisher: MDPI AG
Citation: Therdtatha, Phatthanaphong, Song, Yayi, Tanaka, Masaru, Mariyatun, Mariyatun, Almunifah, Maisaroh, Manurung, Nancy Eka Putri, Indriarsih, Siska, Lu, Yi, Nagata, Koji, Fukami, Katsuya, Ikeda, Tetsuo, Lee, Yuan-Kun, Rahayu, Endang Sutriswati, Nakayama, Jiro (2021-04-22). Gut microbiome of indonesian adults associated with obesity and type 2 diabetes: A cross-sectional study in an asian city, yogyakarta. Microorganisms 9 (5) : 897. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Indonesia is a developing country facing the national problem of the growing obesity and diabetes in its population due to recent drastic dietary and lifestyle changes. To understand the link between the gut microbiome, diet, and health of Indonesian people, fecal microbiomes and metabolomes of 75 Indonesian adults in Yogyakarta City, including obese people (n = 21), type 2 diabetes (T2D) patients (n = 25), and the controls (n = 29) were characterized together with their dietary and medical records. Variations of microbiomes showed a triangular distribution in the principal component analysis, driven by three dominant bacterial genera, namely Bacteroides, Prevotella, and Romboutsia. The Romboutsia-driven microbiome, characterized by low bacterial diversity and high primary bile acids, was associated with fat-driven obesity. The Bacteroides-driven microbiome, which counteracted Prevotella but was associated with Ruminococcaceae concomitantly increased with high-carbohydrate diets, showed positive correlation with T2D indices but negative correlation with body mass index. Notably, Bacteroides fragilis was increased in T2D patients with a decrease in fecal conjugated bile acids, particularly tauroursodeoxycholic acid (TUDCA), a farnesoid X receptor (FXR) antagonist with anti-diabetic activity, while these features disappeared in patients administered metformin. These results indicate that the gut microbiome status of Indonesian adults is differently associated with obesity and T2D under their varied dietary habits. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Microorganisms
ISSN: 2076-2607
DOI: 10.3390/microorganisms9050897
Rights: Attribution 4.0 International
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