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Title: A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Authors: Gao, Yuji 
Nguyen, Dat T. 
Yeo, Trifanny 
Lim, Su Bin
Tan, Wei Xian
Madden, Leigh Edward
Jin, Lin 
Kenan Long, Ji Yong
Bakar Aloweni, Fazila Abu
Angela Liew, Yi Jia
Ling Tan, Mandy Li
Ang, Shin Yuh
Maniya, Sivagame D. O.
Abdelwahab, Ibrahim 
Loh, Kian Ping 
Chen, Chia-Hung
Becker, David Laurence
Leavesley, David
Ho, John S. 
Lim, Chwee Teck 
Issue Date: 21-May-2021
Publisher: American Association for the Advancement of Science
Citation: Gao, Yuji, Nguyen, Dat T., Yeo, Trifanny, Lim, Su Bin, Tan, Wei Xian, Madden, Leigh Edward, Jin, Lin, Kenan Long, Ji Yong, Bakar Aloweni, Fazila Abu, Angela Liew, Yi Jia, Ling Tan, Mandy Li, Ang, Shin Yuh, Maniya, Sivagame D. O., Abdelwahab, Ibrahim, Loh, Kian Ping, Chen, Chia-Hung, Becker, David Laurence, Leavesley, David, Ho, John S., Lim, Chwee Teck (2021-05-21). A flexible multiplexed immunosensor for point-of-care in situ wound monitoring. Science Advances 7 (21) : eabg9614. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor–?, interleukin-6 (IL-6), IL-8, and transforming growth factor–?1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes. © 2021 The Authors, some rights reserved;
Source Title: Science Advances
ISSN: 2375-2548
DOI: 10.1126/sciadv.abg9614
Rights: Attribution 4.0 International
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