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Title: Battling chemoresistance in cancer: Root causes and strategies to uproot them
Authors: Ramos, Alisha
Sadeghi, Samira
Tabatabaeian, Hossein 
Keywords: Cancer
Cancer therapy
Issue Date: 31-Aug-2021
Publisher: MDPI
Citation: Ramos, Alisha, Sadeghi, Samira, Tabatabaeian, Hossein (2021-08-31). Battling chemoresistance in cancer: Root causes and strategies to uproot them. International Journal of Molecular Sciences 22 (17) : 9451. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with major key parameters that control cancer treatment management, such as diagnosis, resistance to the classical and new chemotherapeutic reagents continues to be a significant problem. Intrinsic or acquired chemoresistance leads to cancer recurrence in many cases that eventually causes failure in the successful treatment and death of cancer patients. Various determinants, including tumor heterogeneity and tumor microenvironment, could cause chemoresistance through a diverse range of mechanisms. In this review, we summarize the key determinants and the underlying mechanisms by which chemoresistance appears. We then describe which strategies have been implemented and studied to combat such a lethal phenomenon in the management of cancer treatment, with emphasis on the need to improve the early diagnosis of cancer complemented by combination therapy. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms22179451
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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