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Title: Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
Authors: Zhao, Xiang 
Wu, Liang-Zhe 
Ng, Esther K. Y. 
Leow, Kerisa W. S.
Wei, Qianru 
Gascoigne, Nicholas R. J. 
Brzostek, Joanna 
Keywords: AKT pathway
non-stimulatory peptide MHC
T cell effector functions
T cell receptor
T cell signaling
Issue Date: 11-Oct-2021
Publisher: Frontiers Media S.A.
Citation: Zhao, Xiang, Wu, Liang-Zhe, Ng, Esther K. Y., Leow, Kerisa W. S., Wei, Qianru, Gascoigne, Nicholas R. J., Brzostek, Joanna (2021-10-11). Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck. Frontiers in Immunology 12 : 721722. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Under physiological conditions, CD8+ T cells need to recognize low numbers of antigenic pMHC class I complexes in the presence of a surplus of non-stimulatory, self pMHC class I on the surface of the APC. Non-stimulatory pMHC have been shown to enhance CD8+ T cell responses to low amounts of antigenic pMHC, in a phenomenon called co-agonism, but the physiological significance and molecular mechanism of this phenomenon are still poorly understood. Our data show that co-agonist pMHC class I complexes recruit CD8-bound Lck to the immune synapse to modulate CD8+ T cell signaling pathways, resulting in enhanced CD8+ T cell effector functions and proliferation, both in vitro and in vivo. Moreover, co-agonism can boost T cell proliferation through an extrinsic mechanism, with co-agonism primed CD8+ T cells enhancing Akt pathway activation and proliferation in neighboring CD8+ T cells primed with low amounts of antigen. © Copyright © 2021 Zhao, Wu, Ng, Leow, Wei, Gascoigne and Brzostek.
Source Title: Frontiers in Immunology
ISSN: 1664-3224
DOI: 10.3389/fimmu.2021.721722
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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