Please use this identifier to cite or link to this item:
|Title:||Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck||Authors:||Zhao, Xiang
Ng, Esther K. Y.
Leow, Kerisa W. S.
Gascoigne, Nicholas R. J.
non-stimulatory peptide MHC
T cell effector functions
T cell receptor
T cell signaling
|Issue Date:||11-Oct-2021||Publisher:||Frontiers Media S.A.||Citation:||Zhao, Xiang, Wu, Liang-Zhe, Ng, Esther K. Y., Leow, Kerisa W. S., Wei, Qianru, Gascoigne, Nicholas R. J., Brzostek, Joanna (2021-10-11). Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck. Frontiers in Immunology 12 : 721722. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2021.721722||Rights:||Attribution 4.0 International||Abstract:||Under physiological conditions, CD8+ T cells need to recognize low numbers of antigenic pMHC class I complexes in the presence of a surplus of non-stimulatory, self pMHC class I on the surface of the APC. Non-stimulatory pMHC have been shown to enhance CD8+ T cell responses to low amounts of antigenic pMHC, in a phenomenon called co-agonism, but the physiological significance and molecular mechanism of this phenomenon are still poorly understood. Our data show that co-agonist pMHC class I complexes recruit CD8-bound Lck to the immune synapse to modulate CD8+ T cell signaling pathways, resulting in enhanced CD8+ T cell effector functions and proliferation, both in vitro and in vivo. Moreover, co-agonism can boost T cell proliferation through an extrinsic mechanism, with co-agonism primed CD8+ T cells enhancing Akt pathway activation and proliferation in neighboring CD8+ T cells primed with low amounts of antigen. © Copyright © 2021 Zhao, Wu, Ng, Leow, Wei, Gascoigne and Brzostek.||Source Title:||Frontiers in Immunology||URI:||https://scholarbank.nus.edu.sg/handle/10635/233112||ISSN:||1664-3224||DOI:||10.3389/fimmu.2021.721722||Rights:||Attribution 4.0 International|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
|10_3389_fimmu_2021_721722.pdf||2.73 MB||Adobe PDF|
checked on Mar 16, 2023
This item is licensed under a Creative Commons License