Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-20563-9
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dc.titleAdhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
dc.contributor.authorLe, Anh Phuong
dc.contributor.authorRupprecht, Jean-Francois
dc.contributor.authorMège, René-Marc
dc.contributor.authorToyama, Yusuke
dc.contributor.authorLim, Chwee Teck
dc.contributor.authorLadoux, Benoit
dc.date.accessioned2022-10-13T06:48:21Z
dc.date.available2022-10-13T06:48:21Z
dc.date.issued2021-01-15
dc.identifier.citationLe, Anh Phuong, Rupprecht, Jean-Francois, Mège, René-Marc, Toyama, Yusuke, Lim, Chwee Teck, Ladoux, Benoit (2021-01-15). Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion. Nature Communications 12 (1) : 397. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-20563-9
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/233088
dc.description.abstractApoptotic extrusion is crucial in maintaining epithelial homeostasis. Current literature supports that epithelia respond to extrusion by forming a supracellular actomyosin purse-string in the neighbors. However, whether other actin structures could contribute to extrusion and how forces generated by these structures can be integrated are unknown. Here, we found that during extrusion, a heterogeneous actin network composed of lamellipodia protrusions and discontinuous actomyosin cables, was reorganized in the neighboring cells. The early presence of basal lamellipodia protrusion participated in both basal sealing of the extrusion site and orienting the actomyosin purse-string. The co-existence of these two mechanisms is determined by the interplay between the cell-cell and cell-substrate adhesions. A theoretical model integrates these cellular mechanosensitive components to explain why a dual-mode mechanism, which combines lamellipodia protrusion and purse-string contractility, leads to more efficient extrusion than a single-mode mechanism. In this work, we provide mechanistic insight into extrusion, an essential epithelial homeostasis process. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentDEPT OF ANATOMY
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentINST FOR HEALTH INNOVATION & TECHNOLOGY
dc.description.doi10.1038/s41467-020-20563-9
dc.description.sourcetitleNature Communications
dc.description.volume12
dc.description.issue1
dc.description.page397
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