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Title: Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation
Authors: Zhang, Bin
Lai, Ruenn Chai
Sim, Wei Kian
Choo, Andre Boon Hwa
Lane, Ellen Birgit
Lim, Sai Kiang
Keywords: Exosome
Mesenchymal stem cell
Issue Date: 13-Jan-2021
Publisher: MDPI AG
Citation: Zhang, Bin, Lai, Ruenn Chai, Sim, Wei Kian, Choo, Andre Boon Hwa, Lane, Ellen Birgit, Lim, Sai Kiang (2021-01-13). Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation. International Journal of Molecular Sciences 22 (2) : 1-13. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Severe psoriasis, a chronic inflammatory skin disease is increasingly being effectively managed by targeted immunotherapy but long-term immunotherapy poses health risk and loss of response. Therefore, there is a need for alternative therapy strategies. Mesenchymal stem/stromal cell (MSC) exosomes are widely known for their potent immunomodulatory properties. Here we investigated if topically applied MSC exosomes could alleviate psoriasis-associated inflammation. Topically applied fluorescent exosomes on human skin explants were confined primarily to the stratum corneum with <1% input fluorescence exiting the explant over a 24-h period. Nevertheless, topically applied MSC exosomes in a mouse model of imiquimod (IMQ) psoriasis significantly reduced IL-17 and terminal complement activation complex C5b-9 in the mouse skin. MSC exosomes were previously shown to inhibit complement activation, specifically C5b-9 complex formation through CD59. Infiltration of neutrophils into the stratum corneum is characteristic of psoriasis and neutrophils are a major cellular source of IL-17 in psoriasis through the release of neutrophil extracellular traps (NETs). We propose that topically applied MSC exosomes inhibit complement activation in the stratum corneum and this alleviates IL-17 release by NETS from neutrophils that accumulate in and beneath the stratum corneum. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms22020720
Rights: Attribution 4.0 International
Appears in Collections:Department Publications

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