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Title: A chromosome-level genome assembly of Cairina moschata and comparative genomic analyses
Authors: Jiang, Fan
Jiang, Yaoxin
Wang, Wenxuan
Xiao, Changyi
Lin, Ruiyi
Xie, Tanghui
Sung, Wing-Kin 
Li, Shijun
Jakovli?, Ivan
Chen, Jianhai
Du, Xiaoyong
Issue Date: 30-Jul-2021
Publisher: BioMed Central Ltd
Citation: Jiang, Fan, Jiang, Yaoxin, Wang, Wenxuan, Xiao, Changyi, Lin, Ruiyi, Xie, Tanghui, Sung, Wing-Kin, Li, Shijun, Jakovli?, Ivan, Chen, Jianhai, Du, Xiaoyong (2021-07-30). A chromosome-level genome assembly of Cairina moschata and comparative genomic analyses. BMC Genomics 22 (1) : 581. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: The Muscovy duck (Cairina moschata) is an economically important duck species, with favourable growth and carcass composition parameters in comparison to other ducks. However, limited genomic resources for Muscovy duck hinder our understanding of its evolution and genetic diversity. Results: We combined linked-reads sequencing technology and reference-guided methods for de novo genome assembly. The final draft assembly was 1.12 Gbp with 29 autosomes, one sex chromosome and 4,583 unlocalized scaffolds with an N50 size of 77.35 Mb. Based on universal single-copy orthologues (BUSCO), the draft genome assembly completeness was estimated to be 93.30 %. Genome annotation identified 15,580 genes, with 15,537 (99.72 %) genes annotated in public databases. We conducted comparative genomic analyses and found that species-specific and rapidly expanding gene families (compared to other birds) in Muscovy duck are mainly involved in Calcium signaling, Adrenergic signaling in cardiomyocytes, and GnRH signaling pathways. In comparison to the common domestic duck (Anas platyrhynchos), we identified 104 genes exhibiting strong signals of adaptive evolution (Ka/Ks > 1). Most of these genes were associated with immune defence pathways (e.g. IFNAR1 and TLR5). This is indicative of the existence of differences in the immune responses between the two species. Additionally, we combined divergence and polymorphism data to demonstrate the “faster-Z effect” of chromosome evolution. Conclusions: The chromosome-level genome assembly of Muscovy duck and comparative genomic analyses provide valuable resources for future molecular ecology studies, as well as the evolutionary arms race between the host and influenza viruses. © 2021, The Author(s).
Source Title: BMC Genomics
ISSN: 1471-2164
DOI: 10.1186/s12864-021-07897-4
Rights: Attribution 4.0 International
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