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dc.titleWhole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
dc.contributor.authorAnsari-Pour, Naser
dc.contributor.authorZheng, Yonglan
dc.contributor.authorYoshimatsu, Toshio F.
dc.contributor.authorSanni, Ayodele
dc.contributor.authorAjani, Mustapha
dc.contributor.authorReynier, Jean-Baptiste
dc.contributor.authorTapinos, Avraam
dc.contributor.authorPitt, Jason J.
dc.contributor.authorDentro, Stefan
dc.contributor.authorWoodard, Anna
dc.contributor.authorRajagopal, Padma Sheila
dc.contributor.authorFitzgerald, Dominic
dc.contributor.authorGruber, Andreas J.
dc.contributor.authorOdetunde, Abayomi
dc.contributor.authorPopoola, Abiodun
dc.contributor.authorFalusi, Adeyinka G.
dc.contributor.authorBabalola, Chinedum Peace
dc.contributor.authorOgundiran, Temidayo
dc.contributor.authorIbrahim, Nasiru
dc.contributor.authorBarretina, Jordi
dc.contributor.authorVan Loo, Peter
dc.contributor.authorChen, Mengjie
dc.contributor.authorWhite, Kevin P.
dc.contributor.authorOjengbede, Oladosu
dc.contributor.authorObafunwa, John
dc.contributor.authorHuo, Dezheng
dc.contributor.authorWedge, David C.
dc.contributor.authorOlopade, Olufunmilayo, I
dc.identifier.citationAnsari-Pour, Naser, Zheng, Yonglan, Yoshimatsu, Toshio F., Sanni, Ayodele, Ajani, Mustapha, Reynier, Jean-Baptiste, Tapinos, Avraam, Pitt, Jason J., Dentro, Stefan, Woodard, Anna, Rajagopal, Padma Sheila, Fitzgerald, Dominic, Gruber, Andreas J., Odetunde, Abayomi, Popoola, Abiodun, Falusi, Adeyinka G., Babalola, Chinedum Peace, Ogundiran, Temidayo, Ibrahim, Nasiru, Barretina, Jordi, Van Loo, Peter, Chen, Mengjie, White, Kevin P., Ojengbede, Oladosu, Obafunwa, John, Huo, Dezheng, Wedge, David C., Olopade, Olufunmilayo, I (2021-11-26). Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes. Nature Communications 12 (1) : 6946. ScholarBank@NUS Repository.
dc.description.abstractBlack women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white women of European ancestry. Although inter-ethnic germline variation is known, differential somatic evolution has not been investigated in detail. Analysis of deep whole genomes of 97 breast cancers, with RNA-seq in a subset, from women in Nigeria in comparison with The Cancer Genome Atlas (n = 76) reveal a higher rate of genomic instability and increased intra-tumoral heterogeneity as well as a unique genomic subtype defined by early clonal GATA3 mutations with a 10.5-year younger age at diagnosis. We also find non-coding mutations in bona fide drivers (ZNF217 and SYPL1) and a previously unreported INDEL signature strongly associated with African ancestry proportion, underscoring the need to expand inclusion of diverse populations in biomedical research. Finally, we demonstrate that characterizing tumors for homologous recombination deficiency has significant clinical relevance in stratifying patients for potentially life-saving therapies. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.description.sourcetitleNature Communications
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