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Title: Hypothetical blood-pressure-lowering interventions and risk of stroke and dementia
Authors: Rojas-Saunero, L.P.
Saima Hilal 
Murray, E.J.
Logan, R.W.
Ikram, M.A.
Swanson, S.A.
Keywords: Dementia
Target trial
Issue Date: 27-Nov-2020
Publisher: Springer Science and Business Media B.V.
Citation: Rojas-Saunero, L.P., Saima Hilal, Murray, E.J., Logan, R.W., Ikram, M.A., Swanson, S.A. (2020-11-27). Hypothetical blood-pressure-lowering interventions and risk of stroke and dementia. European Journal of Epidemiology 36 (1) : 69-79. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: We aimed to study the effects of hypothetical interventions on systolic blood pressure (SBP) and smoking on risk of stroke and dementia using data from 15 years of follow-up in the Rotterdam Study. We used data from 4930 individuals, aged 55–80 years, with no prior history of stroke, dementia or cognitive impairment, followed for 15 years within the Rotterdam Study, a population-based cohort. We defined the following sustained interventions on SBP: (1) maintaining SBP below 120 mmHg, (2) maintaining SBP below 140 mmHg, (3) reducing SBP by 10% if above 140 mmHg, (4) reducing SBP by 20% if above 140 mmHg, and a combined intervention of quitting smoking with each of these SBP-lowering strategies. We considered incident stroke and incident dementia diagnoses as outcomes. We applied the parametric g-formula to adjust for baseline and time-varying confounding. The observed 15-year risk for stroke was 10.7%. Compared to no specified intervention (i.e., the “natural course”), all interventions that involved reducing SBP were associated with a stroke risk reduction of about 10% (e.g., reducing SBP by 20% if above 140 mmHg risk ratio: 0.89; 95% CI 0.76, 1). Jointly intervening on SBP and smoking status further decreased the risk of stroke (e.g., risk ratio: 0.83; 95% CI 0.71, 0.94). None of the specified interventions were associated with a substantive change in dementia risk. Our study suggests that a joint intervention on SBP and smoking cessation during later life may reduce stroke risk, while the potential for reducing dementia risk were not observed. © 2020, The Author(s).
Source Title: European Journal of Epidemiology
ISSN: 0393-2990
DOI: 10.1007/s10654-020-00694-5
Rights: Attribution 4.0 International
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