Please use this identifier to cite or link to this item: https://doi.org/10.1093/molbev/msab110
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dc.titleGenomic Basis of Striking Fin Shapes and Colors in the Fighting Fish
dc.contributor.authorWang, Le
dc.contributor.authorSun, Fei
dc.contributor.authorWan, Zi Yi
dc.contributor.authorYe, Baoqing
dc.contributor.authorWen, Yanfei
dc.contributor.authorLiu, Huiming
dc.contributor.authorYang, Zituo
dc.contributor.authorPang, Hongyan
dc.contributor.authorMeng, Zining
dc.contributor.authorFan, Bin
dc.contributor.authorAlfiko, Yuzer
dc.contributor.authorShen, Yubang
dc.contributor.authorBai, Bin
dc.contributor.authorLee, May Shu Qing
dc.contributor.authorPiferrer, Francesc
dc.contributor.authorSchartl, Manfred
dc.contributor.authorMeyer, Axel
dc.contributor.authorYue, Gen Hua
dc.date.accessioned2022-10-12T08:15:51Z
dc.date.available2022-10-12T08:15:51Z
dc.date.issued2021-04-19
dc.identifier.citationWang, Le, Sun, Fei, Wan, Zi Yi, Ye, Baoqing, Wen, Yanfei, Liu, Huiming, Yang, Zituo, Pang, Hongyan, Meng, Zining, Fan, Bin, Alfiko, Yuzer, Shen, Yubang, Bai, Bin, Lee, May Shu Qing, Piferrer, Francesc, Schartl, Manfred, Meyer, Axel, Yue, Gen Hua (2021-04-19). Genomic Basis of Striking Fin Shapes and Colors in the Fighting Fish. Molecular Biology and Evolution 38 (8) : 3383-3396. ScholarBank@NUS Repository. https://doi.org/10.1093/molbev/msab110
dc.identifier.issn0737-4038
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232601
dc.description.abstractResolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long-fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole-genome sequencing, quantitative trait loci mapping, genome-wide association studies, and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino, and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
dc.publisherOxford University Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectcis-regulation
dc.subjectdomestication
dc.subjectevolution
dc.subjectmajor-effect loci
dc.subjectmitfa
dc.subjectzic1/zic4
dc.typeArticle
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1093/molbev/msab110
dc.description.sourcetitleMolecular Biology and Evolution
dc.description.volume38
dc.description.issue8
dc.description.page3383-3396
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