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Title: Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy
Authors: Francis, Rohin
Chong, Jun 
Ramlall, Manish
Bucciarelli-Ducci, Chiara
Clayton, Tim
Dodd, Matthew
Engstrøm, T.
Evans, Richard
Ferreira, Vanessa M.
Fontana, Marianna
Greenwood, John P.
Kharbanda, Rajesh K.
Kim, Won Yong
Kotecha, Tushar
Lønborg, J.T.
Mathur, Anthony
Møller, U.K.
Moon, James
Perkins, Alexander
Rakhit, Roby D.
Yellon, Derek M.
Bøtker, H.E.
Bulluck, Heerajnarain
Hausenloy, Derek J. 
Keywords: Cardioprotection
Cardiovascular magnetic resonance
Myocardial infarct size
Remote ischaemic conditioning
Issue Date: 14-Oct-2021
Publisher: Springer Science and Business Media Deutschland GmbH
Citation: Francis, Rohin, Chong, Jun, Ramlall, Manish, Bucciarelli-Ducci, Chiara, Clayton, Tim, Dodd, Matthew, Engstrøm, T., Evans, Richard, Ferreira, Vanessa M., Fontana, Marianna, Greenwood, John P., Kharbanda, Rajesh K., Kim, Won Yong, Kotecha, Tushar, Lønborg, J.T., Mathur, Anthony, Møller, U.K., Moon, James, Perkins, Alexander, Rakhit, Roby D., Yellon, Derek M., Bøtker, H.E., Bulluck, Heerajnarain, Hausenloy, Derek J. (2021-10-14). Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy. Basic Research in Cardiology 116 (1) : 59. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The effect of limb remote ischaemic conditioning (RIC) on myocardial infarct (MI) size and left ventricular ejection fraction (LVEF) was investigated in a pre-planned cardiovascular magnetic resonance (CMR) substudy of the CONDI-2/ERIC-PPCI trial. This single-blind multi-centre trial (7 sites in UK and Denmark) included 169 ST-segment elevation myocardial infarction (STEMI) patients who were already randomised to either control (n = 89) or limb RIC (n = 80) (4 × 5 min cycles of arm cuff inflations/deflations) prior to primary percutaneous coronary intervention. CMR was performed acutely and at 6 months. The primary endpoint was MI size on the 6 month CMR scan, expressed as median and interquartile range. In 110 patients with 6-month CMR data, limb RIC did not reduce MI size [RIC: 13.0 (5.1–17.1)% of LV mass; control: 11.1 (7.0–17.8)% of LV mass, P = 0.39], or LVEF, when compared to control. In 162 patients with acute CMR data, limb RIC had no effect on acute MI size, microvascular obstruction and LVEF when compared to control. In a subgroup of anterior STEMI patients, RIC was associated with lower incidence of microvascular obstruction and higher LVEF on the acute scan when compared with control, but this was not associated with an improvement in LVEF at 6 months. In summary, in this pre-planned CMR substudy of the CONDI-2/ERIC-PPCI trial, there was no evidence that limb RIC reduced MI size or improved LVEF at 6 months by CMR, findings which are consistent with the neutral effects of limb RIC on clinical outcomes reported in the main CONDI-2/ERIC-PPCI trial. © 2021, The Author(s).
Source Title: Basic Research in Cardiology
ISSN: 0300-8428
DOI: 10.1007/s00395-021-00896-2
Rights: Attribution 4.0 International
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