Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fgene.2020.590672
DC Field | Value | |
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dc.title | Integrative Epigenomic Analysis of Transcriptional Regulation of Human CircRNAs | |
dc.contributor.author | Li, Xue-Cang | |
dc.contributor.author | Tang, Zhi-Dong | |
dc.contributor.author | Peng, Li | |
dc.contributor.author | Li, Yan-Yu | |
dc.contributor.author | Qian, Feng-Cui | |
dc.contributor.author | Zhao, Jian-Mei | |
dc.contributor.author | Ding, Ling-Wen | |
dc.contributor.author | Du, Xiao-Juan | |
dc.contributor.author | Li, Meng | |
dc.contributor.author | Zhang, Jian | |
dc.contributor.author | Bai, Xue-Feng | |
dc.contributor.author | Zhu, Jiang | |
dc.contributor.author | Feng, Chen-Chen | |
dc.contributor.author | Wang, Qiu-Yu | |
dc.contributor.author | Pan, Jian | |
dc.contributor.author | Li, Chun-Quan | |
dc.date.accessioned | 2022-10-12T08:13:49Z | |
dc.date.available | 2022-10-12T08:13:49Z | |
dc.date.issued | 2021-01-25 | |
dc.identifier.citation | Li, Xue-Cang, Tang, Zhi-Dong, Peng, Li, Li, Yan-Yu, Qian, Feng-Cui, Zhao, Jian-Mei, Ding, Ling-Wen, Du, Xiao-Juan, Li, Meng, Zhang, Jian, Bai, Xue-Feng, Zhu, Jiang, Feng, Chen-Chen, Wang, Qiu-Yu, Pan, Jian, Li, Chun-Quan (2021-01-25). Integrative Epigenomic Analysis of Transcriptional Regulation of Human CircRNAs. Frontiers in Genetics 11 : 590672. ScholarBank@NUS Repository. https://doi.org/10.3389/fgene.2020.590672 | |
dc.identifier.issn | 1664-8021 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232571 | |
dc.description.abstract | Circular RNAs (circRNAs) are evolutionarily conserved and abundant non-coding RNAs whose functions and regulatory mechanisms remain largely unknown. Here, we identify and characterize an epigenomically distinct group of circRNAs (TAH-circRNAs), which are transcribed to a higher level than their host genes. By integrative analysis of cistromic and transcriptomic data, we find that compared with other circRNAs, TAH-circRNAs are expressed more abundantly and have more transcription factors (TFs) binding sites and lower DNA methylation levels. Concordantly, TAH-circRNAs are enriched in open and active chromatin regions. Importantly, ChIA-PET results showed that 23–52% of transcription start sites (TSSs) of TAH-circRNAs have direct interactions with cis-regulatory regions, strongly suggesting their independent transcriptional regulation from host genes. In addition, we characterize molecular features of super-enhancer-driven circRNAs in cancer biology. Together, this study comprehensively analyzes epigenomic characteristics of circRNAs and identifies a distinct group of TAH-circRNAs that are independently transcribed via enhancers and super-enhancers by TFs. These findings substantially advance our understanding of the regulatory mechanism of circRNAs and may have important implications for future investigations of this class of non-coding RNAs. © Copyright © 2021 Li, Tang, Peng, Li, Qian, Zhao, Ding, Du, Li, Zhang, Bai, Zhu, Feng, Wang, Pan and Li. | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | circular RNAs | |
dc.subject | epigenomic | |
dc.subject | TAH-circRNAs | |
dc.subject | transcription factors | |
dc.subject | transcriptional regulation | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.3389/fgene.2020.590672 | |
dc.description.sourcetitle | Frontiers in Genetics | |
dc.description.volume | 11 | |
dc.description.page | 590672 | |
Appears in Collections: | Elements Staff Publications |
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