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Title: Integrative Epigenomic Analysis of Transcriptional Regulation of Human CircRNAs
Authors: Li, Xue-Cang
Tang, Zhi-Dong
Peng, Li
Li, Yan-Yu
Qian, Feng-Cui
Zhao, Jian-Mei
Ding, Ling-Wen 
Du, Xiao-Juan
Li, Meng
Zhang, Jian
Bai, Xue-Feng
Zhu, Jiang
Feng, Chen-Chen
Wang, Qiu-Yu
Pan, Jian
Li, Chun-Quan
Keywords: circular RNAs
transcription factors
transcriptional regulation
Issue Date: 25-Jan-2021
Publisher: Frontiers Media S.A.
Citation: Li, Xue-Cang, Tang, Zhi-Dong, Peng, Li, Li, Yan-Yu, Qian, Feng-Cui, Zhao, Jian-Mei, Ding, Ling-Wen, Du, Xiao-Juan, Li, Meng, Zhang, Jian, Bai, Xue-Feng, Zhu, Jiang, Feng, Chen-Chen, Wang, Qiu-Yu, Pan, Jian, Li, Chun-Quan (2021-01-25). Integrative Epigenomic Analysis of Transcriptional Regulation of Human CircRNAs. Frontiers in Genetics 11 : 590672. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Circular RNAs (circRNAs) are evolutionarily conserved and abundant non-coding RNAs whose functions and regulatory mechanisms remain largely unknown. Here, we identify and characterize an epigenomically distinct group of circRNAs (TAH-circRNAs), which are transcribed to a higher level than their host genes. By integrative analysis of cistromic and transcriptomic data, we find that compared with other circRNAs, TAH-circRNAs are expressed more abundantly and have more transcription factors (TFs) binding sites and lower DNA methylation levels. Concordantly, TAH-circRNAs are enriched in open and active chromatin regions. Importantly, ChIA-PET results showed that 23–52% of transcription start sites (TSSs) of TAH-circRNAs have direct interactions with cis-regulatory regions, strongly suggesting their independent transcriptional regulation from host genes. In addition, we characterize molecular features of super-enhancer-driven circRNAs in cancer biology. Together, this study comprehensively analyzes epigenomic characteristics of circRNAs and identifies a distinct group of TAH-circRNAs that are independently transcribed via enhancers and super-enhancers by TFs. These findings substantially advance our understanding of the regulatory mechanism of circRNAs and may have important implications for future investigations of this class of non-coding RNAs. © Copyright © 2021 Li, Tang, Peng, Li, Qian, Zhao, Ding, Du, Li, Zhang, Bai, Zhu, Feng, Wang, Pan and Li.
Source Title: Frontiers in Genetics
ISSN: 1664-8021
DOI: 10.3389/fgene.2020.590672
Rights: Attribution 4.0 International
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