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Title: Dual Antibacterial Effect of In Situ Electrospun Curcumin Composite Nanofibers to Sterilize Drug-Resistant Bacteria
Authors: Liu, Chun-Li
Yang, Jun
Bai, Xiao-Han
Cao, Zhi-Kai
Yang, Chen
Ramakrishna, Seeram 
Yang, Da-Peng
Zhang, Jun
Long, Yun-Ze
Keywords: Curcumin
Drug-resistant bacteria
In situ deposition
Issue Date: 7-Apr-2021
Publisher: Springer
Citation: Liu, Chun-Li, Yang, Jun, Bai, Xiao-Han, Cao, Zhi-Kai, Yang, Chen, Ramakrishna, Seeram, Yang, Da-Peng, Zhang, Jun, Long, Yun-Ze (2021-04-07). Dual Antibacterial Effect of In Situ Electrospun Curcumin Composite Nanofibers to Sterilize Drug-Resistant Bacteria. Nanoscale Research Letters 16 (1) : 54. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Bacterial infection especially caused by multidrug-resistant bacteria still endangers human life. Photodynamic therapy (PDT) can effectively kill bacteria, and nanofiber-based PDT can effectively reduce damage to normal tissues. However, current photosensitizers coated on the surfaces of fibers would release to the wound, causing some side effects. And nanofibers prepared by traditional method exhibit poor adhesion on the wound, which severely reduces the PDT effect due to its short-range effect. Herein, core–shell curcumin composite nanofibers are prepared by in situ electrospinning method via a self-made portable electrospinning device. The obtained composite nanofibers show superior adhesiveness on different biological surface than that of traditional preparation method. Upon 808-nm irradiation, these composite nanofibers effectively produced singlet oxygen (1O2) without curcumin falling off. After these composite nanofibers’ exposure to drug-resistant bacteria, they exhibit dual antibacterial behaviors and efficiently kill the drug-resistant bacteria. These dual antibacterial nanofiber membranes with excellent adhesiveness may benefit the application of wound infection as antibacterial dressing. © 2021, The Author(s).
Source Title: Nanoscale Research Letters
ISSN: 1931-7573
DOI: 10.1186/s11671-021-03513-2
Rights: Attribution 4.0 International
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