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https://doi.org/10.3390/nu13051704
DC Field | Value | |
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dc.title | Supplementation of omega 3 during pregnancy and the risk of preterm birth: A systematic review and meta-analysis | |
dc.contributor.author | Serra, Ramon | |
dc.contributor.author | Peñailillo, Reyna | |
dc.contributor.author | Monteiro, Lara J. | |
dc.contributor.author | Monckeberg, Max | |
dc.contributor.author | Peña, Macarena | |
dc.contributor.author | Moyano, Lia | |
dc.contributor.author | Brunner, Camila | |
dc.contributor.author | Vega, Georgina | |
dc.contributor.author | Choolani, Mahesh | |
dc.contributor.author | Illanes, Sebastian E. | |
dc.date.accessioned | 2022-10-12T08:07:07Z | |
dc.date.available | 2022-10-12T08:07:07Z | |
dc.date.issued | 2021-05-18 | |
dc.identifier.citation | Serra, Ramon, Peñailillo, Reyna, Monteiro, Lara J., Monckeberg, Max, Peña, Macarena, Moyano, Lia, Brunner, Camila, Vega, Georgina, Choolani, Mahesh, Illanes, Sebastian E. (2021-05-18). Supplementation of omega 3 during pregnancy and the risk of preterm birth: A systematic review and meta-analysis. Nutrients 13 (5) : 1704. ScholarBank@NUS Repository. https://doi.org/10.3390/nu13051704 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232476 | |
dc.description.abstract | Preterm birth (PTB) is a major cause of neonatal death and long-term consequences for the newborn. This review aims to update the evidence about the potential benefit of pharmacological supplementation with omega 3 fatty acids during pregnancy on the incidence of PTB. The Medline, Embase, Cochrane Library and Central databases were searched until 28 June 2020 for RCTs in which omega 3 supplementation was used versus placebo to reduce PTB risk. Data from 37 trials were analyzed. We found an 11% reduction in PTB risk (RR(risk ratios), 0.89; 95% CI (confidence intervals), 0.82 to 0.97) in trials using omega 3 supplements versus placebo. Regarding early PTB (ePTB), there was a 27% reduction in the risk of ePTB (RR, 0.73; 95% CI, 0.58 to 0.92). However, after sensitivity analyses, there were no significant differences in PTB and ePTB risk (PTB RR, 0.92; 95% CI, 0.83 to 1.01, ePTB RR, 0.82; 95% CI, 0.61 to 1.09). We conclude that omega 3 supplementation during pregnancy does not reduce the risk of PTB and ePTB. More studies are required to determine the effect of omega 3 supplementations during pregnancy and the risk of detrimental fetal outcomes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.publisher | MDPI AG | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | Meta-analysis | |
dc.subject | Omega 3 supplementation | |
dc.subject | Preterm birth | |
dc.type | Review | |
dc.contributor.department | DEPT OF OBSTETRICS & GYNAECOLOGY | |
dc.description.doi | 10.3390/nu13051704 | |
dc.description.sourcetitle | Nutrients | |
dc.description.volume | 13 | |
dc.description.issue | 5 | |
dc.description.page | 1704 | |
Appears in Collections: | Elements Staff Publications |
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