Please use this identifier to cite or link to this item: https://doi.org/10.3390/nu13051704
Title: Supplementation of omega 3 during pregnancy and the risk of preterm birth: A systematic review and meta-analysis
Authors: Serra, Ramon
Peñailillo, Reyna
Monteiro, Lara J.
Monckeberg, Max
Peña, Macarena
Moyano, Lia
Brunner, Camila
Vega, Georgina
Choolani, Mahesh 
Illanes, Sebastian E.
Keywords: Meta-analysis
Omega 3 supplementation
Preterm birth
Issue Date: 18-May-2021
Publisher: MDPI AG
Citation: Serra, Ramon, Peñailillo, Reyna, Monteiro, Lara J., Monckeberg, Max, Peña, Macarena, Moyano, Lia, Brunner, Camila, Vega, Georgina, Choolani, Mahesh, Illanes, Sebastian E. (2021-05-18). Supplementation of omega 3 during pregnancy and the risk of preterm birth: A systematic review and meta-analysis. Nutrients 13 (5) : 1704. ScholarBank@NUS Repository. https://doi.org/10.3390/nu13051704
Rights: Attribution 4.0 International
Abstract: Preterm birth (PTB) is a major cause of neonatal death and long-term consequences for the newborn. This review aims to update the evidence about the potential benefit of pharmacological supplementation with omega 3 fatty acids during pregnancy on the incidence of PTB. The Medline, Embase, Cochrane Library and Central databases were searched until 28 June 2020 for RCTs in which omega 3 supplementation was used versus placebo to reduce PTB risk. Data from 37 trials were analyzed. We found an 11% reduction in PTB risk (RR(risk ratios), 0.89; 95% CI (confidence intervals), 0.82 to 0.97) in trials using omega 3 supplements versus placebo. Regarding early PTB (ePTB), there was a 27% reduction in the risk of ePTB (RR, 0.73; 95% CI, 0.58 to 0.92). However, after sensitivity analyses, there were no significant differences in PTB and ePTB risk (PTB RR, 0.92; 95% CI, 0.83 to 1.01, ePTB RR, 0.82; 95% CI, 0.61 to 1.09). We conclude that omega 3 supplementation during pregnancy does not reduce the risk of PTB and ePTB. More studies are required to determine the effect of omega 3 supplementations during pregnancy and the risk of detrimental fetal outcomes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Nutrients
URI: https://scholarbank.nus.edu.sg/handle/10635/232476
ISSN: 2072-6643
DOI: 10.3390/nu13051704
Rights: Attribution 4.0 International
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