Please use this identifier to cite or link to this item: https://doi.org/10.7554/elife.69861
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dc.titleIntegrin ?5?1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity
dc.contributor.authorDi Russo, Jacopo
dc.contributor.authorYoung, Jennifer L.
dc.contributor.authorWegner, Julian WR
dc.contributor.authorSteins, Timmy
dc.contributor.authorKessler, Horst
dc.contributor.authorSpatz, Joachim P.
dc.date.accessioned2022-10-12T08:02:24Z
dc.date.available2022-10-12T08:02:24Z
dc.date.issued2021-09-23
dc.identifier.citationDi Russo, Jacopo, Young, Jennifer L., Wegner, Julian WR, Steins, Timmy, Kessler, Horst, Spatz, Joachim P. (2021-09-23). Integrin ?5?1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity. eLife 10 : e69861. ScholarBank@NUS Repository. https://doi.org/10.7554/elife.69861
dc.identifier.issn2050-084X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232405
dc.description.abstractNanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extracellular matrix receptors influences collective cell migration. In wound healing, basal keratinocytes collectively migrate on a fibronectin-rich provisional basement membrane to re-epithelialize the injured skin. Among other receptors, the fibronectin receptor integrin ?5?1 plays a pivotal role in this process. Using a highly specific integrin ?5?1 peptidomimetic combined with nanopatterned hydrogels, we show that keratinocyte sheets regulate their migration ability at an optimal integrin ?5?1 nanospacing. This efficiency relies on the effective propagation of stresses within the cell monolayer independent of substrate stiffness. For the first time, this work highlights the importance of extracellular matrix receptor nanoscale organization required for efficient tissue regeneration. © Di Russo et al.
dc.publishereLife Sciences Publications Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentCOLLEGE OF DESIGN AND ENGINEERING
dc.description.doi10.7554/elife.69861
dc.description.sourcetitleeLife
dc.description.volume10
dc.description.pagee69861
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