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Title: Integrin ?5?1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity
Authors: Di Russo, Jacopo
Young, Jennifer L. 
Wegner, Julian WR
Steins, Timmy
Kessler, Horst
Spatz, Joachim P.
Issue Date: 23-Sep-2021
Publisher: eLife Sciences Publications Ltd
Citation: Di Russo, Jacopo, Young, Jennifer L., Wegner, Julian WR, Steins, Timmy, Kessler, Horst, Spatz, Joachim P. (2021-09-23). Integrin ?5?1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity. eLife 10 : e69861. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extracellular matrix receptors influences collective cell migration. In wound healing, basal keratinocytes collectively migrate on a fibronectin-rich provisional basement membrane to re-epithelialize the injured skin. Among other receptors, the fibronectin receptor integrin ?5?1 plays a pivotal role in this process. Using a highly specific integrin ?5?1 peptidomimetic combined with nanopatterned hydrogels, we show that keratinocyte sheets regulate their migration ability at an optimal integrin ?5?1 nanospacing. This efficiency relies on the effective propagation of stresses within the cell monolayer independent of substrate stiffness. For the first time, this work highlights the importance of extracellular matrix receptor nanoscale organization required for efficient tissue regeneration. © Di Russo et al.
Source Title: eLife
ISSN: 2050-084X
DOI: 10.7554/elife.69861
Rights: Attribution 4.0 International
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