Please use this identifier to cite or link to this item: https://doi.org/10.3389/fcell.2021.749364
DC FieldValue
dc.titleZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer
dc.contributor.authorNeyrinck-Leglantier, Deborah
dc.contributor.authorLesage, Julien
dc.contributor.authorBlacher, Silvia
dc.contributor.authorBonnomet, Arnaud
dc.contributor.authorHunziker, Walter
dc.contributor.authorNoël, Agnès
dc.contributor.authorDormoy, Valerian
dc.contributor.authorNawrocki-Raby, Beatrice
dc.contributor.authorGilles, Christine
dc.contributor.authorPolette, Myriam
dc.date.accessioned2022-10-12T07:52:51Z
dc.date.available2022-10-12T07:52:51Z
dc.date.issued2021-12-06
dc.identifier.citationNeyrinck-Leglantier, Deborah, Lesage, Julien, Blacher, Silvia, Bonnomet, Arnaud, Hunziker, Walter, Noël, Agnès, Dormoy, Valerian, Nawrocki-Raby, Beatrice, Gilles, Christine, Polette, Myriam (2021-12-06). ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer. Frontiers in Cell and Developmental Biology 9 : 749364. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2021.749364
dc.identifier.issn2296-634X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232267
dc.description.abstractDelocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression. Copyright © 2021 Neyrinck-Leglantier, Lesage, Blacher, Bonnomet, Hunziker, Noël, Dormoy, Nawrocki-Raby, Gilles and Polette.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectepithelial plasticity
dc.subjectepithelial-mesenchymal transition
dc.subjectimmune infiltrate
dc.subjectlung cancer
dc.subjecttumor microenvironment
dc.subjectZO-1
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.3389/fcell.2021.749364
dc.description.sourcetitleFrontiers in Cell and Developmental Biology
dc.description.volume9
dc.description.page749364
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fcell_2021_749364.pdf2.43 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

16
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons