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Title: Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
Authors: McWhinney, Sean R.
Abé, C.
Alda, Martin
Benedetti, Francesco
Bøen, E.
del Mar Bonnin, C.
Borgers, Tiana
Brosch, Katharina
Canales-Rodríguez, E.J.
Cannon, Dara M.
Dannlowski, Udo
Díaz-Zuluaga, A.M.
Elvsåshagen, T.
Eyler, Lisa T.
Fullerton, Janice M.
Goikolea, Jose M.
Goltermann, Janik
Grotegerd, Dominik
Haarman, Bartholomeus C. M.
Hahn, Tim
Howells, Fleur M.
Ingvar, Martin
Kircher, Tilo T. J.
Krug, Axel
Kuplicki, Rayus T.
Landén, M.
Lemke, Hannah
Liberg, Benny
Lopez-Jaramillo, Carlos
Malt, Ulrik F.
Martyn, Fiona M.
Mazza, Elena
McDonald, Colm
McPhilemy, Genevieve
Meier, Sandra
Meinert, Susanne
Meller, Tina
Melloni, Elisa M. T.
Mitchell, Philip B.
Nabulsi, Leila.
Nenadic, Igor
Opel, Nils
Ophoff, Roel A.
Overs, Bronwyn J.
Pfarr, Julia-Katharina
Pineda-Zapata, Julian A.
Pomarol-Clotet, Edith
Raduà, J.
Repple, Jonathan
Richter, Maike
Ringwald, Kai G.
Roberts, Gloria
Salvador, Raymond
Savitz, Jonathan
Schmitt, Simon
Schofield, Peter R.
Sim, Kang 
Stein, Dan J.
Stein, Frederike
Temmingh, Henk S.
Thiel, Katharina
van Haren, Neeltje E. M.
Gestel, Holly Van
Vargas, Cristian
Vieta, Eduard
Vreeker, Annabel
Waltemate, Lena
Yatham, Lakshmi N.
Ching, Christopher R. K.
Andreassen, Ole
Thompson, Paul M.
Hajek, Tomas
for the ENIGMA Bipolar Disorders Working Group.
Issue Date: 16-Apr-2021
Publisher: Springer Nature
Citation: McWhinney, Sean R., Abé, C., Alda, Martin, Benedetti, Francesco, Bøen, E., del Mar Bonnin, C., Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, E.J., Cannon, Dara M., Dannlowski, Udo, Díaz-Zuluaga, A.M., Elvsåshagen, T., Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C. M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Kircher, Tilo T. J., Krug, Axel, Kuplicki, Rayus T., Landén, M., Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M. T., Mitchell, Philip B., Nabulsi, Leila., Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia-Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, J., Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, van Haren, Neeltje E. M., Gestel, Holly Van, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R. K., Andreassen, Ole, Thompson, Paul M., Hajek, Tomas, for the ENIGMA Bipolar Disorders Working Group. (2021-04-16). Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals. Molecular Psychiatry 26 (11) : 6806-6819. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression. © 2021, The Author(s).
Source Title: Molecular Psychiatry
ISSN: 1359-4184
DOI: 10.1038/s41380-021-01098-x
Rights: Attribution 4.0 International
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