Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.semcdb.2021.06.003
DC FieldValue
dc.titleMechanical processes underlying precise and robust cell matching
dc.contributor.authorZhang, Shaobo
dc.contributor.authorSaunders, Timothy
dc.date.accessioned2022-10-11T08:07:08Z
dc.date.available2022-10-11T08:07:08Z
dc.date.issued2021-06-01
dc.identifier.citationZhang, Shaobo, Saunders, Timothy (2021-06-01). Mechanical processes underlying precise and robust cell matching. Seminars in Cell and Developmental Biology 120 : 75-84. ScholarBank@NUS Repository. https://doi.org/10.1016/j.semcdb.2021.06.003
dc.identifier.issn1084-9521
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232197
dc.description.abstractDuring the development of complicated multicellular organisms, the robust formation of specific cell-cell connections (cell matching) is required for the generation of precise tissue structures. Mismatches or misconnections can lead to various diseases. Diverse mechanical cues, including differential adhesion and temporally varying cell contractility, are involved in regulating the process of cell-cell recognition and contact formation. Cells often start the process of cell matching through contact via filopodia protrusions, mediated by specific adhesion interactions at the cell surface. These adhesion interactions give rise to differential mechanical signals that can be further perceived by the cells. In conjunction with contractions generated by the actomyosin networks within the cells, this differentially coded adhesion information can be translated to reposition and sort cells. Here, we review the role of these different cell matching components and suggest how these mechanical factors cooperate with each other to facilitate specificity in cell-cell contact formation. © 2021 The Authors
dc.publisherElsevier Ltd
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2021
dc.subjectActomyosin
dc.subjectAdhesion molecules
dc.subjectCell adhesion
dc.subjectCell matching
dc.subjectFilopodia
dc.typeReview
dc.contributor.departmentMECHANOBIOLOGY INSTITUTE
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1016/j.semcdb.2021.06.003
dc.description.sourcetitleSeminars in Cell and Developmental Biology
dc.description.volume120
dc.description.page75-84
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