Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41541-021-00282-y
Title: A single-dose live attenuated chimeric vaccine candidate against Zika virus
Authors: Chin, Wei-Xin 
Lee, Regina Ching Hua 
Kaur, Parveen 
Lew, Tian Sheng
Yogarajah, Thinesshwary 
Kong, Hao Yuin 
Teo, Zi-Yun 
Salim, Cyrill Kafi 
Zhang, Rong-Rong
Li, Xiao-Feng
Alonso, Sylvie 
Qin, Cheng-Feng
Chu, Justin Jang Hann 
Issue Date: 29-Jan-2021
Publisher: Nature Research
Citation: Chin, Wei-Xin, Lee, Regina Ching Hua, Kaur, Parveen, Lew, Tian Sheng, Yogarajah, Thinesshwary, Kong, Hao Yuin, Teo, Zi-Yun, Salim, Cyrill Kafi, Zhang, Rong-Rong, Li, Xiao-Feng, Alonso, Sylvie, Qin, Cheng-Feng, Chu, Justin Jang Hann (2021-01-29). A single-dose live attenuated chimeric vaccine candidate against Zika virus. npj Vaccines 6 (1) : 20. ScholarBank@NUS Repository. https://doi.org/10.1038/s41541-021-00282-y
Rights: Attribution 4.0 International
Abstract: The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature sensitivity, attenuation of neurovirulence in suckling mice, and attenuation of pathogenicity in interferon deficient adult AG129 mice. VacDZ may be administered as a traditional live virus vaccine, or as a DNA-launched vaccine that produces live VacDZ in vivo after delivery. Both vaccine formulations induce a protective immune response against Zika virus in AG129 mice, which includes neutralising antibodies and a strong Th1 response. This study demonstrates that VacDZ is a safe and effective vaccine candidate against Zika virus. © 2021, The Author(s).
Source Title: npj Vaccines
URI: https://scholarbank.nus.edu.sg/handle/10635/232187
ISSN: 2059-0105
DOI: 10.1038/s41541-021-00282-y
Rights: Attribution 4.0 International
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