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Title: Functional role of p16INK4A and n-myc downstream regulated gene 1 (NDRG1) up-regulation in cervical carcinoma
Authors: LAU WEN MIN
Keywords: p16, NDRG1, cervical, cancer, upregulation, microarray
Issue Date: 5-Jun-2007
Citation: LAU WEN MIN (2007-06-05). Functional role of p16INK4A and n-myc downstream regulated gene 1 (NDRG1) up-regulation in cervical carcinoma. ScholarBank@NUS Repository.
Abstract: Cancer of the cervix is the second most common cancer for women worldwide; in Singapore, cervical cancer is the fifth most common cancer in females. The objective of this study is to employ gene expression profiling of cervical cancer to identify novel differentially regulated genes which may serve as molecular diagnostic markers in cervical cancer.We constructed subtracted cDNA libraries from tumourous and non-tumourous cervical tissue taken from a single patient, and these libraries were used to generate cDNA microarrays. Amongst the differentially expressed genes, we focused on the study of p16 and NDRG1 as these two genes showed the most significant up-regulation in cervical cancer tissues compared to non-cancerous and normal cervical tissues. This current work focuses on elucidating the functional roles of p16 and NDRG1 in cervical cancer. Our findings suggest that p16 and NDRG1 are able to mediate apoptosis and cell cycle arrest respectively via p53-associated pathways.
Appears in Collections:Ph.D Theses (Open)

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