Please use this identifier to cite or link to this item:
DC FieldValue
dc.titleWilms Tumor 1 Mutations Are Independent Poor Prognostic Factors in Pediatric Acute Myeloid Leukemia
dc.contributor.authorWang, Yin
dc.contributor.authorWeng, Wen-Jun
dc.contributor.authorZhou, Dun-Hua
dc.contributor.authorFang, Jian-Pei
dc.contributor.authorMishra, Srishti
dc.contributor.authorChai, L.
dc.contributor.authorXu, Lu-Hong
dc.identifier.citationWang, Yin, Weng, Wen-Jun, Zhou, Dun-Hua, Fang, Jian-Pei, Mishra, Srishti, Chai, L., Xu, Lu-Hong (2021-04-21). Wilms Tumor 1 Mutations Are Independent Poor Prognostic Factors in Pediatric Acute Myeloid Leukemia. Frontiers in Oncology 11 : 632094. ScholarBank@NUS Repository.
dc.description.abstractThe prognostic impact of Wilms tumor 1 (WT1) mutations remains controversial for patients with acute myeloid leukemia (AML). Here, we aimed to determine the clinical implication of WT1 mutations in a large cohort of pediatric AML. The clinical data of 870 pediatric patients with AML were downloaded from the therapeutically applicable research to generate effective treatment (TARGET) dataset. We analyzed the prevalence, clinical profile, and prognosis of AML patients with WT1 mutations in this cohort. Our results showed that 6.7% of total patients harbored WT1 mutations. These WT1 mutations were closely associated with normal cytogenetics (P<0.001), FMS-like tyrosine kinase 3/internal tandem duplication (FLT3/ITD) mutations (P<0.001), and low complete remission induction rates (P<0.01). Compared to the patients without WT1 mutations, patients with WT1 mutations had a worse 5-year event-free survival (21.7 ± 5.5% vs 48.9 ± 1.8%, P<0.001) and a worse overall survival (41.4 ± 6.6% vs 64.3 ± 1.7%, P<0.001). Moreover, patients with both WT1 and FLT3/ITD mutations had a dismal prognosis. Compared to chemotherapy alone, hematopoietic stem cell transplantation tended to improve the prognoses of WT1-mutated patients. Multivariate analysis demonstrated that WT1 mutations conferred an independent adverse impact on event-free survival (hazard ratio 1.910, P = 0.001) and overall survival (hazard ratio 1.709, P = 0.020). In conclusion, our findings have demonstrated that WT1 mutations are independent poor prognostic factors in pediatric AML. © Copyright © 2021 Wang, Weng, Zhou, Fang, Mishra, Chai and Xu.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.subjectacute myeloid leukemia
dc.subjectFLT3/ITD mutations
dc.subjectpediatric patients
dc.subjectprognostic factors
dc.subjectWT1 mutations
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.sourcetitleFrontiers in Oncology
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fonc_2021_632094.pdf2.39 MBAdobe PDF



Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons