Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.abe4323
DC FieldValue
dc.titleA distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception
dc.contributor.authorPhua, Siew Cheng
dc.contributor.authorTan, Yu Lin
dc.contributor.authorKok, Alison Maun Yeng
dc.contributor.authorSenol, Esra
dc.contributor.authorChiam, Christine Jin Hui
dc.contributor.authorLee, Chun-Yao
dc.contributor.authorPeng, Yanmin
dc.contributor.authorLim, Auriel Theodora Jacobea
dc.contributor.authorMohammad, Hasan
dc.contributor.authorLim, Jing-Xuan
dc.contributor.authorFu, Yu
dc.date.accessioned2022-10-11T07:58:51Z
dc.date.available2022-10-11T07:58:51Z
dc.date.issued2021-05-07
dc.identifier.citationPhua, Siew Cheng, Tan, Yu Lin, Kok, Alison Maun Yeng, Senol, Esra, Chiam, Christine Jin Hui, Lee, Chun-Yao, Peng, Yanmin, Lim, Auriel Theodora Jacobea, Mohammad, Hasan, Lim, Jing-Xuan, Fu, Yu (2021-05-07). A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception. Science Advances 7 (19) : eabe4323. ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.abe4323
dc.identifier.issn2375-2548
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232089
dc.description.abstractThe motivation to eat is not only shaped by nutrition but also competed by external stimuli including pain. How the mouse hypothalamus, the feeding regulation center, integrates nociceptive inputs to modulate feeding is unclear. Within the key nociception relay center parabrachial nucleus (PBN), we demonstrated that neurons projecting to the lateral hypothalamus (LHPBN) are nociceptive yet distinct from danger-encoding central amygdala-projecting (CeAPBN) neurons. Activation of LHPBN strongly suppressed feeding by limiting eating frequency and also reduced motivation to work for food reward. Refined approach-avoidance paradigm revealed that suppression of LHPBN, but not CeAPBN, sustained motivation to obtain food. The effect of LHPBN neurons on feeding was reversed by suppressing downstream LHVGluT2 neurons. Thus, distinct from a circuit for fear and escape responses, LHPBN neurons channel nociceptive signals to LHVGluT2 neurons to suppress motivational drive for feeding. Our study provides a new perspective in understanding feeding regulation by external competing stimuli. © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
dc.publisherAmerican Association for the Advancement of Science
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentDEPT OF PSYCHOLOGY
dc.description.doi10.1126/sciadv.abe4323
dc.description.sourcetitleScience Advances
dc.description.volume7
dc.description.issue19
dc.description.pageeabe4323
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1126_sciadv_abe4323.pdf1.4 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

8
checked on Jan 22, 2023

Page view(s)

17
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons