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Title: Heparin-tagged pla-peg copolymer-encapsulated biochanin a-loaded (Mg/al) ldh nanoparticles recommended for non-thrombogenic and anti-proliferative stent coating
Authors: Adepu, Shivakalyani
Luo, Hongrong
Ramakrishna, Seeram 
Keywords: Bioachanin A
Controlled release
Drug-eluting stent
Layered double hydroxide nanoparticles
Stent thrombosis
Issue Date: 21-May-2021
Publisher: MDPI
Citation: Adepu, Shivakalyani, Luo, Hongrong, Ramakrishna, Seeram (2021-05-21). Heparin-tagged pla-peg copolymer-encapsulated biochanin a-loaded (Mg/al) ldh nanoparticles recommended for non-thrombogenic and anti-proliferative stent coating. International Journal of Molecular Sciences 22 (11) : 5433. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Drug-eluting stents have been widely implanted to prevent neointimal hyperplasia associated with bare metal stents. Conventional polymers and anti-proliferative drugs suffer from stent thrombosis due to the non-selective nature of the drugs and hypersensitivity to polymer degradation products. Alternatively, various herbal anti-proliferative agents are sought, of which biochanin A (an isoflavone phytoestrogen) was known to have anti-proliferative and vasculoprotective action. PLA-PEG diblock copolymer was tagged with heparin, whose degradation releases heparin locally and prevents thrombosis. To get a controlled drug release, biochanin A was loaded in layered double hydroxide nanoparticles (LDH), which are further encapsulated in a heparin-tagged PLA-PEG copolymer. LDH nanoparticles are synthesized by a co-precipitation process; in situ as well as ex situ loading of biochanin A were done. PLA-PEG-heparin copolymer was synthesized by esterification reaction, and the drug-loaded nanoparticles are coated. The formulation was characterized by FTIR, XRD, DSC, DLS, and TEM. In vitro drug release studies, protein adhesion, wettability, hemocompat-ibility, and degradation studies were performed. The drug release was modeled by mathematical models to further emphasize the mechanism of drug release. The developed drug-eluting stent coating is non-thrombogenic, and it offers close to zero-order release for 40 days, with complete polymer degradation in 14 weeks. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms22115433
Rights: Attribution 4.0 International
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