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dc.titleChoriocapillaris microvasculature dysfunction in systemic hypertension
dc.contributor.authorChua, Jacqueline
dc.contributor.authorLe, Thu-Thao
dc.contributor.authorTan, Bingyao
dc.contributor.authorKe, Mengyuan
dc.contributor.authorLi, Chi
dc.contributor.authorWong, Damon Wing Kee
dc.contributor.authorTan, Anna C. S.
dc.contributor.authorLamoureux, Ecosse
dc.contributor.authorWong, Tien Yin
dc.contributor.authorChin, Calvin Woon Loong
dc.contributor.authorSchmetterer, Leopold
dc.identifier.citationChua, Jacqueline, Le, Thu-Thao, Tan, Bingyao, Ke, Mengyuan, Li, Chi, Wong, Damon Wing Kee, Tan, Anna C. S., Lamoureux, Ecosse, Wong, Tien Yin, Chin, Calvin Woon Loong, Schmetterer, Leopold (2021-02-25). Choriocapillaris microvasculature dysfunction in systemic hypertension. Scientific Reports 11 (1) : 4603. ScholarBank@NUS Repository.
dc.description.abstractWe examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm2; 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm2; 3551 ± 41) and healthy controls (365 ± 11 µm2; 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.description.sourcetitleScientific Reports
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