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Title: Choriocapillaris microvasculature dysfunction in systemic hypertension
Authors: Chua, Jacqueline 
Le, Thu-Thao 
Tan, Bingyao
Ke, Mengyuan
Li, Chi
Wong, Damon Wing Kee
Tan, Anna C. S. 
Lamoureux, Ecosse 
Wong, Tien Yin 
Chin, Calvin Woon Loong 
Schmetterer, Leopold 
Issue Date: 25-Feb-2021
Publisher: Nature Research
Citation: Chua, Jacqueline, Le, Thu-Thao, Tan, Bingyao, Ke, Mengyuan, Li, Chi, Wong, Damon Wing Kee, Tan, Anna C. S., Lamoureux, Ecosse, Wong, Tien Yin, Chin, Calvin Woon Loong, Schmetterer, Leopold (2021-02-25). Choriocapillaris microvasculature dysfunction in systemic hypertension. Scientific Reports 11 (1) : 4603. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm2; 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm2; 3551 ± 41) and healthy controls (365 ± 11 µm2; 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease. © 2021, The Author(s).
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-021-84136-6
Rights: Attribution 4.0 International
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