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Title: Conferring materials with antibacterial properties
Keywords: Biofilm, Antibacterial, Biomaterials, Surface Functionalization, Bone Cement
Issue Date: 19-Jul-2007
Citation: SHI ZHILONG (2007-07-19). Conferring materials with antibacterial properties. ScholarBank@NUS Repository.
Abstract: With the widespread use of implants in modern medicine and the spread of pathogens in hospitals, the issue of biofilm-related infections is of increasing importance. This thesis describes the research carried out on the development of different surface and bulk modification techniques for introducing antibacterial properties on materials including polymer, metal and activated carbon. Different types of quaternary ammonium groups were covalently immobilized on polymer and activated carbon substrates. Silver nanoparticles which were obtained by the photoreduction of silver ions by bipyridium-type quaternary ammonium can further enhance the antibacterial activity. Antibacterial property was conferred on stainless steel via polyelectrolyte multilayers of quaternized polyethylenimine and poly(acrylic acid). In addition, two new strategies were developed to confer antibacterial properties to the commercial poly(methyl methacrylate) bone cement: the first strategy uses chitosan nanoparticles which may be further derivatized with quaternary ammonium groups while the second employs norfloxacin-containing monomer, as one of the components in the commercial poly(methyl methacrylate) bone cement. These modified cements offer two distinct advantages: high mechanical strength even with an additive to bone cement powder loading of 15%, and long lasting antibacterial effect.
Appears in Collections:Ph.D Theses (Open)

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