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Title: Supramolecular architectures formed by copolymers and cyclodextrins and their applications for gene delivery
Keywords: Cyclodextrin, polyrotaxane, oligoethylenimine, inclusion complexation, polyethylenimine, non-viral gene delivery vectors
Issue Date: 22-Oct-2007
Citation: YANG CHUAN (2007-10-22). Supramolecular architectures formed by copolymers and cyclodextrins and their applications for gene delivery. ScholarBank@NUS Repository.
Abstract: Cyclodextrins (CDs) are cyclic oligosaccharides, mainly consisting of 6, 7 or 8 I?-D-glucopyranose units (I?-CD, I?-CD and I?-CD) linked by I?-(1,4) bonds. These water-soluble, biocompatible oligosccharides do no elicit immune responses and have low toxicity in animals and humans. The objective of this thesis was to develop novel CD-based cationic polymers and supramolecular architectures for efficient gene delivery. In this study, a series of novel cationic star polymers consisting of i?!-CD core and oligoethylenimine (OEI) arms and cationic supramolecular polyrotaxanes composed of multiple OEI-grafted CDs threaded on various copolymer chains have been synthesized. Results indicated that these cationic polymers not only could efficiently compact plasmid DNA into small nanoparticles, but also showed excellent gene transfection efficiency and low in vitro cytotoxicity in various cell lines. Hence, they are promising non-viral gene delivery vectors and can be widely used in future gene therapy applications.
Appears in Collections:Ph.D Theses (Open)

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