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Title: Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs
Keywords: Biodegradable polymers, Nanoparticles, Vitamin E TPGS, Protein drug delivery, Targeting, Folate
Issue Date: 8-May-2007
Citation: LEE SIE HUEY (2007-05-08). Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs. ScholarBank@NUS Repository.
Abstract: Firstly, nanoparticles of poly(lactide) a?? vitamin E TPGS (PLA-TPGS) copolymers with various PLA:TPGS component ratios were prepared by double emulsion technique for protein drug formulation with bovine serum albumin (BSA) as a model protein. Influence of PLA:TPGS component ratio and BSA loading level on drug encapsulation efficiency and in vitro drug release behavior was investigated. The stability of the released BSA was studied. The PLA-TPGS nanoparticles are found of great potential to be an efficient delivery vehicle for proteins. Secondly, doxorubicin-loaded nanoparticles composed of vitamin E TPGS-folate (TPGS-FOL) conjugate and doxorubicin-poly(lactide-co-glycolide)-vitamin E TPGS conjugate with various blend ratio were fabricated by solvent extraction/evaporation method to produce a folate-receptor-targeted drug vehicle for tumor-specific drug delivery. Folate-mediated nanoparticles showed increased targeting ability against folate receptors overexpressed cancer cells compared with free drug and nanoparticles without TPGS-FOL, demonstrating the applicability of TPGS-FOL nanoparticles as potential carrier for tumor-selective drug delivery of various therapeutic agents.
Appears in Collections:Master's Theses (Open)

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