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Title: Formulation of superparamagnetic Iron oxides by Nanoparticles of Biodegradable polymer for magnetic resonance imaging (MRI)
Authors: NG YEE WOON
Keywords: Nanoparticle formulation; superparamagnetic iron oxide; biocompatible and biodegradable polymer; magnetic resonance imaging (MRI); contrast agent
Issue Date: 13-Apr-2007
Citation: NG YEE WOON (2007-04-13). Formulation of superparamagnetic Iron oxides by Nanoparticles of Biodegradable polymer for magnetic resonance imaging (MRI). ScholarBank@NUS Repository.
Abstract: The objective of this study was to develop and evaluate magnetic nanoparticles prepared by encapsulating superparamagnetic iron oxides (IOs) with biocompatible and biodegradable polymer, methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-mPEG) using the water-in-oil-in-water double emulsion technique. Their physicochemical properties were characterized by laser light scattering, field emission scanning electron microscopy, transmission electron microscopy and inductively coupled plasma-mass spectrometry. The vibrating sample magnetometer and superconducting quantum interference device were used for magnetization measurements. Quantitative and qualitative magnetic resonance imaging (MRI) analyses were conducted to determine the relaxation properties of the nanoparticles and their contrast effect on images. The nanoparticles were spherical and less than 250nm in diameter. They showed increased saturation magnetization, improved r2 and r2* relaxivities, and enhanced contrast effects of MR images. The remarkable enhancement in the MR contrast efficiency of the IO loaded PLGA-mPEG nanoparticles over the commercial IOs ResovistA?, suggests that these nanoparticles could be potential MRI contrast agent.
Appears in Collections:Master's Theses (Open)

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