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Title: Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes
Authors: YU LANLAN
Keywords: antimicrobial peptides, peptide-lipid interaction, fluorescence correlation spectroscopy, lipopolysaccharide, peptide action mechanism, membranes
Issue Date: 2-Mar-2007
Citation: YU LANLAN (2007-03-02). Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes. ScholarBank@NUS Repository.
Abstract: Antimicrobial peptides (AMPs) are considered a promising substitute or addition for conventional antibiotics due to the inability of bacteria to develop resistance against them. They target bacterial membranes leading to bacterial lysis and death. In a previous study an artificial antimicrobial peptide, V4, has been designed and showed high antimicrobial activity, low cytotoxic activity and low hemolytic activity. In this thesis the interaction between V4 and different membrane components was investigated by fluorescence correlation spectroscopy (FCS), Langmuir film balance and atomic force microscopy. The study examined the specific properties of V4 and unraveled its action mechanism. The activity and mechanism of V4 was compared to other antimicrobial peptides magainin 2, melittin and polymyxin B. As the necessity for the understanding of V4 binding to bacterial membrane, the aggregation behavior of main target of V4, LPS, was studied using a new method based on FCS.
Appears in Collections:Ph.D Theses (Open)

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