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Title: Myocardial protection and therapeutic angiogenesis using peptide and embryonic stem cell transplantation
Keywords: embryonic stem cell, angiogenesis, endothelial progenitor cell, myocardial infarction, inflammatory cytokines, peptide therapy
Issue Date: 29-May-2007
Citation: RUFAIHAH BTE ABDUL JALIL (2007-05-29). Myocardial protection and therapeutic angiogenesis using peptide and embryonic stem cell transplantation. ScholarBank@NUS Repository.
Abstract: Ischemic heart disease, a condition caused by artherosclerosis; the narrowing or blockage of the blood vessels due to deposition of cholesterol plaques on their walls is deadly. Over time, deficient oxygenation and nutrient supply to the heart muscle occurs leading to massive death of functional cardiomyocytes. First part of the research focuses on the influence of a novel nona-peptide known as des-aspartate-angiotensin-I on the inflammatory cytokines expression in the infarcted myocardium. Being an endogenous peptide of the renin-angiotensin cascade, it is capable of exerting cardioprotective actions in pathologies where angiotensin II is involved. Second part of the research focuses on endothelial progenitor and endothelial cell differentiation of human embryonic stem cells. Cell-based therapy is one of the more recent advances in the field of regenerative medicine. Transplantation of these cells into the infarcted myocardium has the potential to augment new blood vessel growth hence reducing the extent of myocardial damage.
Appears in Collections:Ph.D Theses (Open)

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