Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/23075
Title: Helicobacter pylori: It's role in gastroesophageal reflux disease
Authors: HO YAN WING
Keywords: Helicobacter pylori, Virulence genes, Lewis antigens, Proinflammatory mechanism, Gastroesophageal reflux disease
Issue Date: 30-Mar-2007
Citation: HO YAN WING (2007-03-30). Helicobacter pylori: It's role in gastroesophageal reflux disease. ScholarBank@NUS Repository.
Abstract: The role of Helicobacter pylori in Gastroesophageal reflux disease (GERD) is questioned when increase incidences of GERD coincided with the decline in H. pylori infection. Stomach (antrum, body and cardia) and oesophagus biopsies from 155 randomized GERD-symptomatic patients were examined for H. pylori. Of the 53 H. pylori-positive patients, 16 harboured the organism in oesophageal biopsies. Topological distribution and clinical outcomes of infection were independent of virulence genes expression and H. pylori-related carditis. Characterization of vacA alleles in isolates suggested the presence of multiple H. pylori strains. In addition, host and bacterial Lewis antigens were shown not to be involved in bacterial adhesion. H. pylori-infected non-neoplastic oesophageal cells (HET-1A) caused early apoptosis and activated proinflammatory cytokine pathways via p38 MAPK and NF-i?
URI: http://scholarbank.nus.edu.sg/handle/10635/23075
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ACKNOWLEDGEMENTS.pdf10.34 kBAdobe PDF

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Table of Contents.pdf111.33 kBAdobe PDF

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Summary.pdf78.58 kBAdobe PDF

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LIST OF ABBREVIATIONS.pdf42.29 kBAdobe PDF

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LIST OF FIGURES.pdf34.21 kBAdobe PDF

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LIST OF TABLES.pdf17.71 kBAdobe PDF

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ListofPublications.pdf105.18 kBAdobe PDF

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Introduction.pdf34.76 kBAdobe PDF

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Literature Survey.pdf268.88 kBAdobe PDF

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Materials and Method.pdf321.36 kBAdobe PDF

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Results.pdf11.9 MBAdobe PDF

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Discussion.pdf244.71 kBAdobe PDF

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References.pdf331.23 kBAdobe PDF

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Appendix.pdf214.85 kBAdobe PDF

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