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Title: Nanoparticle Formulations of Diagnostic Agents for Medical Imaging
Authors: WANG YAN
Keywords: Nanoparticle; superparamagnetic iron oxide; quantum dots; biocompatible and biodegradable polymer; magnetic resonance imaging; medical imaging
Issue Date: 29-Mar-2007
Citation: WANG YAN (2007-03-29). Nanoparticle Formulations of Diagnostic Agents for Medical Imaging. ScholarBank@NUS Repository.
Abstract: Superparamagnetic iron oxides (IOs) are widely used for magnetic resonance imaging (MRI). Quantum dots (QDs) are a new class of fluorescent probes of sharp brightness and tunable multiple colors. Both of IOs and QDs, however, have problems in stability and toxicity. This project is proposed to formulate IOs and QDs by nanoparticles of biodegradable polymers to solve the problems. IOs loaded PLGA-mPEG nanoparticles and QDs loaded PLGA and PLGA-TPGS nanoparticles were prepared by double emulsion and solvent evaporation method and characterized by various state-of-the-art techniques for particle size and size distribution, surface morphology, surface charge, in vitro IOs/QDs release, and magnetic/fluorescent properties. The nanoparticle formulation of IOs increased the magnetization, relaxivities, and MRI contrast effect. The nanoparticle formulations of QDs showed emission spectra similar to that of free QDs, lower cytotoxicity and higher cell uptake efficiency, which could be used as potent fluorescent probes for cellular and biomedical imaging.
Appears in Collections:Master's Theses (Open)

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