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Title: Part 1: Combinatorial synthesis of N-Heterocycles Part 2: Development of polymer-supported Hantzsch Ester
Keywords: Combinatorial synthesis, N-Heterocycles, Polymer-supported, Hantzsch Ester
Issue Date: 28-Aug-2007
Citation: HE RONGJUN (2007-08-28). Part 1: Combinatorial synthesis of N-Heterocycles Part 2: Development of polymer-supported Hantzsch Ester. ScholarBank@NUS Repository.
Abstract: This thesis is composed by two parts - Part 1: Combinatorial synthesis of N-heterocycles and Part 2: Development of a polymer-supported Hantzsch ester.Part 1 focuses on the combinatorial synthesis of pharmaceutically and medicinally important N-heterocycles. This part of the thesis comprises four projects. The first two projects studied the combinatorial solid-phase synthesis of xanthines. The third project involves the combinatorial solution-phase synthesis of polycyclic guanines and the fourth project investigated the microwave-assisted solid-phase synthesis of pyrazolidine-3,5-diones. All these synthesis were novel and highly efficient, and could find applicability in drug discovery.Part 2 focuses on the design and development of polymer-supported Hantzsch ester. A polymer-supported Hantzsch ester was successfully developed with the assistance of microwave irradiation, and it has been successfully applied for the reductions of I?,I?-unsaturated aldehydes, imines, and activated benzoquinones. This polymer-supported Hantzsch ester showed equal or better reducing ability than the traditional Hantzsch ester.
Appears in Collections:Ph.D Theses (Open)

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