Please use this identifier to cite or link to this item: https://doi.org/10.1136/bmjopen-2020-047907
Title: Protein supplementation versus standard feeds in underweight critically ill children: a pilot dual-centre randomised controlled trial protocol
Authors: Wong, Judith Ju Ming
Ong, Jacqueline Soo May
Ong, Chengsi
Allen, John Carsen
Gandhi, Mihir
Fan, Lijia
Taylor, Ryan
Lim, Joel Kian Boon
Poh, Pei Fen
Chiou, Fang Kuan
Lee, Jan Hau
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
PARENTERAL-NUTRITION
ENERGY-EXPENDITURE
PEDIATRIC INDEX
MORTALITY 3
REQUIREMENTS
MALNUTRITION
MULTICENTER
NITROGEN
OUTCOMES
DEFICIENCY
Issue Date: 1-Jan-2022
Publisher: BMJ PUBLISHING GROUP
Citation: Wong, Judith Ju Ming, Ong, Jacqueline Soo May, Ong, Chengsi, Allen, John Carsen, Gandhi, Mihir, Fan, Lijia, Taylor, Ryan, Lim, Joel Kian Boon, Poh, Pei Fen, Chiou, Fang Kuan, Lee, Jan Hau (2022-01-01). Protein supplementation versus standard feeds in underweight critically ill children: a pilot dual-centre randomised controlled trial protocol. BMJ OPEN 12 (1). ScholarBank@NUS Repository. https://doi.org/10.1136/bmjopen-2020-047907
Abstract: Introduction Protein-energy malnutrition, increased catabolism and inadequate nutritional support leads to loss of lean body mass with muscle wasting and delayed recovery in critical illness. However, there remains clinical equipoise regarding the risks and benefits of protein supplementation. This pilot trial will determine the feasibility of performing a larger multicentre trial to determine if a strategy of protein supplementation in critically ill children with body mass index (BMI) z-score ≤-2 is superior to standard enteral nutrition in reducing the length of stay in the paediatric intensive care unit (PICU). Methods and analysis This is a randomised controlled trial of 70 children in two PICUs in Singapore. Children with BMI z-score ≤-2 on PICU admission, who are expected to require invasive mechanical ventilation for more than 48 hours, will be randomised (1:1 allocation) to protein supplementation of ≥1.5 g/kg/day in addition to standard nutrition, or standard nutrition alone for 7 days after enrolment or until PICU discharge, whichever is earlier. Feasibility outcomes for the trial include effective screening, satisfactory enrolment rate, timely protocol implementation (within first 72 hours) and protocol adherence. Secondary outcomes include mortality, PICU length of stay, muscle mass, anthropometric measurements and functional outcomes. Ethics and dissemination The trial protocol was approved by the institutional review board of both participating centres (Singhealth Centralised Institutional Review Board and National Healthcare Group Domain Specific Review Board) under the reference number 2020/2742. Findings of the trial will be disseminated through peer-reviewed journals and scientific conferences. Trial registration number NCT04565613.
Source Title: BMJ OPEN
URI: https://scholarbank.nus.edu.sg/handle/10635/230347
ISSN: 2044-6055,2044-6055
DOI: 10.1136/bmjopen-2020-047907
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