Please use this identifier to cite or link to this item: https://doi.org/10.1128/Spectrum.00593-21
Title: Novel Freshwater Cyanophages Provide New Insights into Evolutionary Relationships between Freshwater and Marine Cyanophages
Authors: Zhang, Dong 
He, Yiliang 
Gin, Karina Yew-Hoong 
Keywords: cyanophage
Synechococcus
phylogenetic analysis
Issue Date: 1-Oct-2021
Publisher: AMER SOC MICROBIOLOGY
Citation: Zhang, Dong, He, Yiliang, Gin, Karina Yew-Hoong (2021-10-01). Novel Freshwater Cyanophages Provide New Insights into Evolutionary Relationships between Freshwater and Marine Cyanophages. MICROBIOLOGY SPECTRUM 9 (2). ScholarBank@NUS Repository. https://doi.org/10.1128/Spectrum.00593-21
Abstract: Cyanobacteria and cyanophages are present widely in both freshwater and marine environments. However, freshwater cyanophages remain unknown largely due to the small numbers of cyanophage isolates despite their ecological and environmental significance. In this study, we present the characterization of two novel lytic freshwater cyanophages isolated from a tropical inland lake in Singapore, namely, cyanopodovirus S-SRP01 and cyanomyovirus S-SRM01, infecting two different strains of Synechococcus spp. Functional annotation of S-SRP01 and S-SRM01 genomes revealed a high degree of homology with marine cyanophages. Phylogenetic trees of concatenated genes and whole-genome alignment provided further evidence that S-SRP01 is close evolutionarily to marine cyanopodoviruses, while S-SRM01 is evolutionarily close to marine cyanomyoviruses. Few genetic similarities between freshwater and marine cyanophages have been identified in previous studies. The isolation of S-SRP01 and SSRM01 expand current knowledge on freshwater cyanophages infecting Synechococcus spp. Their high degree of gene sharing provides new insights into the evolutionary relationships between freshwater and marine cyanophages. This relatedness is further supported by the discovery of similar phenomenon from other freshwater viral metagenomes.
Source Title: MICROBIOLOGY SPECTRUM
URI: https://scholarbank.nus.edu.sg/handle/10635/230304
ISSN: 2165-0497
DOI: 10.1128/Spectrum.00593-21
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