Please use this identifier to cite or link to this item:
https://doi.org/10.1097/00007890-199001000-00008
DC Field | Value | |
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dc.title | Proteinuria in cyclosporine-treated renal transplant recipients. | |
dc.contributor.author | Vathsala, A | |
dc.contributor.author | Verani, R | |
dc.contributor.author | Schoenberg, L | |
dc.contributor.author | Lewis, RM | |
dc.contributor.author | Van Buren, CT | |
dc.contributor.author | Kerman, RH | |
dc.contributor.author | Kahan, BD | |
dc.date.accessioned | 2022-08-01T05:55:26Z | |
dc.date.available | 2022-08-01T05:55:26Z | |
dc.date.issued | 1990-01 | |
dc.identifier.citation | Vathsala, A, Verani, R, Schoenberg, L, Lewis, RM, Van Buren, CT, Kerman, RH, Kahan, BD (1990-01). Proteinuria in cyclosporine-treated renal transplant recipients.. Transplantation 49 (1) : 35-41. ScholarBank@NUS Repository. https://doi.org/10.1097/00007890-199001000-00008 | |
dc.identifier.issn | 00411337 | |
dc.identifier.issn | 15346080 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/229621 | |
dc.description.abstract | Of 704 renal transplant recipients receiving long-term cyclosporine immunosuppression, 71 patients experienced proteinuria greater than 1 g/24 hr beyond the first month posttransplant. Eight patients displayed transient proteinuria, defined as lasting less than 3 months. In most cases this condition was attributed to biopsy-proved acute rejection. The transient proteinuria cohort experienced good graft outcome--namely, 87.5% one-year and 52.5% five-year actuarial graft survivals, which was similar to that observed in patients without proteinuria. In contrast, 52.4% of the 63 patients with nontransient proteinuria experienced graft loss within a median time of 6.1 months. The one- and five-year actuarial graft survivals in patients with nontransient proteinuria were 75.3% and 37.5%, respectively. Among the 63 patients with nontransient proteinuria, histopathologic diagnosis included chronic rejection in 19, transplant glomerulopathy in 14, acute rejection in 9, glomerulonephritis (GN) in 7 including 2 cases of membranous GN, and nonspecific interstitial fibrosis in 10 cases. Despite the overall poor prognosis for graft survival among the entire cohort of patients with nontransient proteinuria, the seven with allograft GN maintained prolonged graft function. They showed an 83.3% five-year actuarial graft survival versus 31.2% in patients with other causes of proteinuria (P = 0.043). These results suggest that posttransplant proteinuria in CsA-treated renal transplant recipients arises primarily as a consequence of allograft rejection and portends a poor graft outcome. | |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
dc.source | Elements | |
dc.subject | Cyclosporins | |
dc.subject | Female | |
dc.subject | Glomerulonephritis | |
dc.subject | Graft Rejection | |
dc.subject | Graft Survival | |
dc.subject | Humans | |
dc.subject | Kidney | |
dc.subject | Kidney Transplantation | |
dc.subject | Male | |
dc.subject | Postoperative Complications | |
dc.subject | Proteinuria | |
dc.subject | Transplantation, Homologous | |
dc.subject | Vascular Diseases | |
dc.type | Article | |
dc.date.updated | 2022-07-23T15:40:18Z | |
dc.contributor.department | DEPT OF MEDICINE | |
dc.description.doi | 10.1097/00007890-199001000-00008 | |
dc.description.sourcetitle | Transplantation | |
dc.description.volume | 49 | |
dc.description.issue | 1 | |
dc.description.page | 35-41 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Proteinuria in CyA Treated Recipients_Transplantation 1990 .pdf | 785.57 kB | Adobe PDF | CLOSED | Published |
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