Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11096-018-0652-6
DC FieldValue
dc.titleUnintentional and intentional non-adherence to immunosuppressive medications in renal transplant recipients
dc.contributor.authorGriva, Konstadina
dc.contributor.authorNeo, Hui Ling Michelle
dc.contributor.authorVathsala, Anantharaman
dc.date.accessioned2022-07-25T07:28:35Z
dc.date.available2022-07-25T07:28:35Z
dc.date.issued2018-10-01
dc.identifier.citationGriva, Konstadina, Neo, Hui Ling Michelle, Vathsala, Anantharaman (2018-10-01). Unintentional and intentional non-adherence to immunosuppressive medications in renal transplant recipients. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY 40 (5) : 1234-1241. ScholarBank@NUS Repository. https://doi.org/10.1007/s11096-018-0652-6
dc.identifier.issn22107703
dc.identifier.issn22107711
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/229126
dc.description.abstractBackground Non-adherence to immunosuppressive medications following renal transplantation is a risk factor for rejection and graft loss. Despite the dire consequences, adherence lapses, both unintentional and intentional, are common and poorly understood. Objective The present study sets to compare the rates and determinants of unintentional, intentional and overall self-reported non-adherence. Setting Outpatient clinic at the National University Centre for Organ Transplantation, Singapore. Method This was a cross-sectional survey administered to N = 152 renal transplant recipients. Main outcome measure They completed the Transplant Effects Questionnaire, Beliefs about Medications Questionnaire, Multidimensional Scale of Perceived Social Support, the Depression, Anxiety and Stress Scale, and the Medication Adherence Report Scale. Clinical and laboratory information were also assessed. Results The prevalence rates for overall, unintentional, and intentional self-reported non-adherence were 19.7, 47.4, and 15.1% respectively. Unintentional non-adherence was predicted by engagement in formal work, a primary diagnosis of autoimmune nephritis, and being a recipient of a living-donor renal transplant (i.e. stable characteristics). In contrast, intentional non-adherence was predicted by co-morbid burden and patients’ evaluation of the side effects of their medications. Overall non-adherence was predicted by a deliberate decision-making process involving the weighing of the costs of using immunosuppressive drugs against their perceived benefits. Conclusion The survey highlighted the importance of making a distinction between unintentional and intentional non-adherence in renal transplant recipients, and suggested that modifiable factors may be targeted in different ways in interventions to increase adherence.
dc.language.isoen
dc.publisherSPRINGER
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPharmacology & Pharmacy
dc.subjectImmunosuppressive medications
dc.subjectIntentional
dc.subjectNon-adherence
dc.subjectRenal transplant
dc.subjectSelf-reported
dc.subjectSingapore
dc.subjectUnintentional
dc.subjectQUALITY-OF-LIFE
dc.subjectKIDNEY-TRANSPLANTATION
dc.subjectSOCIAL SUPPORT
dc.subjectRISK-FACTORS
dc.subjectADHERENCE
dc.subjectBELIEFS
dc.subjectMEDICINES
dc.subjectANXIETY
dc.subjectIMPACT
dc.subjectQUESTIONNAIRE
dc.typeArticle
dc.date.updated2022-07-22T11:29:58Z
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF PSYCHOLOGY
dc.description.doi10.1007/s11096-018-0652-6
dc.description.sourcetitleINTERNATIONAL JOURNAL OF CLINICAL PHARMACY
dc.description.volume40
dc.description.issue5
dc.description.page1234-1241
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY - Intentional and non Intenional Non Adherence.pdf952.4 kBAdobe PDF

CLOSED

Published

SCOPUSTM   
Citations

16
checked on Dec 2, 2022

Page view(s)

41
checked on Dec 1, 2022

Download(s)

1
checked on Dec 1, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.