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https://doi.org/10.1007/s11882-021-01015-w
Title: | Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19-a Primer for Clinicians | Authors: | Chee, Jeremy Loh, Woei Shyang Liu, Zheng Mullol, Joaquim Wang, De Yun |
Keywords: | COVID-19 Pandemic Epidemiology Pathogenesis Pathophysiology Mechanism of action |
Issue Date: | 1-Jun-2021 | Publisher: | CURRENT MEDICINE GROUP | Citation: | Chee, Jeremy, Loh, Woei Shyang, Liu, Zheng, Mullol, Joaquim, Wang, De Yun (2021-06-01). Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19-a Primer for Clinicians. CURRENT ALLERGY AND ASTHMA REPORTS 21 (6). ScholarBank@NUS Repository. https://doi.org/10.1007/s11882-021-01015-w | Abstract: | Purpose of Review: Increasing knowledge of the pathogenesis of the SARS-CoV-2 infection and the complex interaction between host and viral factors have allowed clinicians to stratify the severity of COVID-19 infection. Epidemiological data has also helped to model viral carriage and infectivity. This review presents a comprehensive summary of the pathophysiology of COVID-19, the mechanisms of action of the SARS-CoV-2 virus, and the correlation with the clinical and biochemical characteristics of the disease. Recent Findings: ACE2 and TMPRSS2 receptors have emerged as a key player in the mechanism of infection of SARS-CoV-2. Their distribution throughout the body has been shown to impact the organ-specific manifestations of COVID-19. The immune-evasive and subsequently immunoregulative properties of SARS-CoV-2 are also shown to be implicated in disease proliferation and progression. Summary: Information gleaned from the virological properties of SARS-CoV-2 is consistent with and reflects the clinical behavior of the COVID-19 infection. Further study of specific clinical phenotypes and severity classes of COVID-19 may assist in the development of targeted therapeutics to halt progression of disease from mild to moderate-severe. As the understanding of the pathophysiology and mechanism of action of SARS-CoV-2 continues to grow, it is our hope that better and more effective treatment options continue to emerge. | Source Title: | CURRENT ALLERGY AND ASTHMA REPORTS | URI: | https://scholarbank.nus.edu.sg/handle/10635/229002 | ISSN: | 1529-7322 1534-6315 |
DOI: | 10.1007/s11882-021-01015-w |
Appears in Collections: | Staff Publications Elements |
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