Please use this identifier to cite or link to this item:
Title: Design and synthesis of novel metal complex-protein conjugation agents for applications in bio-imaging
Authors: WANG TAO
Keywords: metal-protein conjugates, bio-imaging, somatostatin, intercalation
Issue Date: 18-Jun-2010
Citation: WANG TAO (2010-06-18). Design and synthesis of novel metal complex-protein conjugation agents for applications in bio-imaging. ScholarBank@NUS Repository.
Abstract: Targeting particular cells or tissues for imaging e.g. proliferative cells or for transporting drug molecules plays a vital role in cancer treatment and represents an area of high scientific interest. In order to contribute to a better detection of proliferative cells, a sophisticated metal-DOTA imaging agent was designed that is able to specifically interact with disulfide bridges of proteins by intercalating into accessible disulfide bridges via two sequential Michael addition-elimination reactions. Such DOTA-protein conjugates are highly versatile since they can be labeled with 68Ga for PET or paramagnetic metals such as Gd(?) for MR imaging. In addition, a folate-metal-DOTA conjugate has been prepared as well as a novel approach that facilitates somatostatin-metal-DOTA conjugates has been designed for targeted delivery and first attempts have been undertaken to achieve this challenging goal.
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
master_thesis_WT.pdf4.02 MBAdobe PDF



Page view(s)

checked on Apr 8, 2019


checked on Apr 8, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.