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https://doi.org/10.1007/s00125-019-04979-7
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dc.title | Short-term strength and balance training does not improve quality of life but improves functional status in individuals with diabetic peripheral neuropathy: a randomised controlled trial | |
dc.contributor.author | Venkataraman, Kavita | |
dc.contributor.author | Tai, Bee Choo | |
dc.contributor.author | Khoo, Eric YH | |
dc.contributor.author | Tavintharan, Subramaniam | |
dc.contributor.author | Chandran, Kurumbian | |
dc.contributor.author | Hwang, Siew Wai | |
dc.contributor.author | Phua, Melissa SLA | |
dc.contributor.author | Wee, Hwee Lin | |
dc.contributor.author | Koh, Gerald CH | |
dc.contributor.author | Tai, E Shyong | |
dc.date.accessioned | 2022-07-08T06:40:30Z | |
dc.date.available | 2022-07-08T06:40:30Z | |
dc.date.issued | 2019-12-01 | |
dc.identifier.citation | Venkataraman, Kavita, Tai, Bee Choo, Khoo, Eric YH, Tavintharan, Subramaniam, Chandran, Kurumbian, Hwang, Siew Wai, Phua, Melissa SLA, Wee, Hwee Lin, Koh, Gerald CH, Tai, E Shyong (2019-12-01). Short-term strength and balance training does not improve quality of life but improves functional status in individuals with diabetic peripheral neuropathy: a randomised controlled trial. DIABETOLOGIA 62 (12) : 2200-2210. ScholarBank@NUS Repository. https://doi.org/10.1007/s00125-019-04979-7 | |
dc.identifier.issn | 0012-186X | |
dc.identifier.issn | 1432-0428 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/228114 | |
dc.description.abstract | Aims/hypothesis: The aim of this study was to test the effectiveness of a structured strength and balance training intervention in improving health-related quality of life (HRQoL) and functional status in individuals with diabetic peripheral neuropathy (DPN). Methods: The study was a single-blind parallel-group randomised controlled trial comparing 2 months of once-weekly home-based strength and balance training against standard medical therapy. Participants were patients with physician-diagnosed type 2 diabetes and neuropathy recruited from five public sector institutions in Singapore between July 2014 and October 2017. Participants were block-randomised to intervention or control arms. Outcomes were assessed at baseline, 2 months and 6 months by a trained assessor blinded to group assignment. Primary outcomes were change in physical component summary (PCS) score of SF-36v2 (a 36-item generic HRQoL instrument that has been validated for use in Singapore) and EQ-5D-5L index score (derived from a five-item generic HRQoL instrument [EQ-5D-5L]) over 6 months. Secondary outcomes were change in functional status (timed up-and-go [TUG], five times sit-to-stand [FTSTS], functional reach, static balance, ankle muscle strength and knee range of motion) and balance confidence over 6 months. Mean differences in scores between groups were compared using mixed models. Results: Of the 143 participants randomised (intervention, n = 70; control, n = 73), 67 participants were included in each arm for the final intention-to-treat analysis. The two groups were similar, except in terms of sex. There were no significant differences between groups on the primary outcomes of PCS score (mean difference [MD] 1.56 [95% CI −1.75, 4.87]; p = 0.355) and EQ-5D-5L index score (MD 0.02 [95% CI −0.01, 0.06]; p = 0.175). There were significant improvements in TUG test performance (MD −1.14 [95% CI −2.18, −0.1] s; p = 0.032), FTSTS test performance (MD −1.31 [95% CI −2.12, −0.51] s; p = 0.001), ankle muscle strength (MD 4.18 [95% CI 0.4, 7.92] N; p = 0.031), knee range of motion (MD 6.82 [95% CI 2.87, 10.78]°; p = 0.001) and balance confidence score (MD 6.17 [95% CI 1.89, 10.44]; p = 0.005). No adverse events due to study participation or study intervention were reported. Conclusions/interpretation: Short-term structured strength and balance training did not influence HRQoL but produced sustained improvements in functional status and balance confidence at 6 months. More intensive interventions may be needed to influence HRQoL in these individuals. However, this intervention may be a useful treatment option for individuals with DPN to reduce the risk of falls and injuries. Trial registration: ClinicalTrials.gov NCT02115932 Funding: This work was supported by the National Medical Research Council, Singapore. | |
dc.language.iso | en | |
dc.publisher | SPRINGER | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Endocrinology & Metabolism | |
dc.subject | Balance | |
dc.subject | Diabetes | |
dc.subject | Diabetic neuropathy | |
dc.subject | Functional ability | |
dc.subject | Muscle strength | |
dc.subject | Physical therapy | |
dc.subject | Quality of life | |
dc.subject | PERCEIVED MOBILITY | |
dc.subject | FOOT ULCERATION | |
dc.subject | RISK-FACTORS | |
dc.subject | EXERCISE | |
dc.subject | HEALTH | |
dc.subject | PEOPLE | |
dc.subject | ASSOCIATION | |
dc.subject | POPULATION | |
dc.subject | SEVERITY | |
dc.subject | GAIT | |
dc.type | Article | |
dc.date.updated | 2022-07-06T08:00:18Z | |
dc.contributor.department | COMMUNITY,OCCUPATIONAL & FAMILY MEDICINE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | DEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH) | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1007/s00125-019-04979-7 | |
dc.description.sourcetitle | DIABETOLOGIA | |
dc.description.volume | 62 | |
dc.description.issue | 12 | |
dc.description.page | 2200-2210 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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