Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41551-021-00829-3
DC FieldValue
dc.titleTowards translational optogenetics
dc.contributor.authorBansal, Akshaya
dc.contributor.authorShikha, Swati
dc.contributor.authorZhang, Yong
dc.date.accessioned2022-07-01T05:47:02Z
dc.date.available2022-07-01T05:47:02Z
dc.date.issued2022-01-13
dc.identifier.citationBansal, Akshaya, Shikha, Swati, Zhang, Yong (2022-01-13). Towards translational optogenetics. NATURE BIOMEDICAL ENGINEERING. ScholarBank@NUS Repository. https://doi.org/10.1038/s41551-021-00829-3
dc.identifier.issn2157-846X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227600
dc.description.abstractOptogenetics is widely used to interrogate the neural circuits underlying disease and has most recently been harnessed for therapeutic applications. The optogenetic toolkit consists of light-responsive proteins that modulate specific cellular functions, vectors for the delivery of the transgenes that encode the light-responsive proteins to targeted cellular populations, and devices for the delivery of light of suitable wavelengths at effective fluence rates. A refined toolkit with a focus towards translational uses would include efficient and safer viral and non-viral gene-delivery vectors, increasingly red-shifted photoresponsive proteins, nanomaterials that efficiently transduce near-infrared light deep into tissue, and wireless implantable light-delivery devices that allow for spatiotemporally precise interventions at clinically relevant tissue depths. In this Review, we examine the current optogenetics toolkit and the most notable preclinical and translational uses of optogenetics, and discuss future methodological and translational developments and bottlenecks.
dc.language.isoen
dc.publisherNATURE PORTFOLIO
dc.sourceElements
dc.subjectScience & Technology
dc.subjectTechnology
dc.subjectEngineering, Biomedical
dc.subjectEngineering
dc.subjectUP-CONVERSION NANOPARTICLES
dc.subjectADENOASSOCIATED VIRUS AAV
dc.subjectRESTORES VISUAL RESPONSES
dc.subjectRETINAL BIPOLAR CELLS
dc.subjectOPTICAL CONTROL
dc.subjectGENE DELIVERY
dc.subjectSPATIOTEMPORAL CONTROL
dc.subjectPARKINSONS-DISEASE
dc.subjectMOTOR THALAMUS
dc.subjectFACTOR-IX
dc.typeReview
dc.date.updated2022-06-30T10:55:33Z
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1038/s41551-021-00829-3
dc.description.sourcetitleNATURE BIOMEDICAL ENGINEERING
dc.published.statePublished
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