Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41551-021-00829-3
Title: Towards translational optogenetics
Authors: Bansal, Akshaya 
Shikha, Swati 
Zhang, Yong 
Keywords: Science & Technology
Technology
Engineering, Biomedical
Engineering
UP-CONVERSION NANOPARTICLES
ADENOASSOCIATED VIRUS AAV
RESTORES VISUAL RESPONSES
RETINAL BIPOLAR CELLS
OPTICAL CONTROL
GENE DELIVERY
SPATIOTEMPORAL CONTROL
PARKINSONS-DISEASE
MOTOR THALAMUS
FACTOR-IX
Issue Date: 13-Jan-2022
Publisher: NATURE PORTFOLIO
Citation: Bansal, Akshaya, Shikha, Swati, Zhang, Yong (2022-01-13). Towards translational optogenetics. NATURE BIOMEDICAL ENGINEERING. ScholarBank@NUS Repository. https://doi.org/10.1038/s41551-021-00829-3
Abstract: Optogenetics is widely used to interrogate the neural circuits underlying disease and has most recently been harnessed for therapeutic applications. The optogenetic toolkit consists of light-responsive proteins that modulate specific cellular functions, vectors for the delivery of the transgenes that encode the light-responsive proteins to targeted cellular populations, and devices for the delivery of light of suitable wavelengths at effective fluence rates. A refined toolkit with a focus towards translational uses would include efficient and safer viral and non-viral gene-delivery vectors, increasingly red-shifted photoresponsive proteins, nanomaterials that efficiently transduce near-infrared light deep into tissue, and wireless implantable light-delivery devices that allow for spatiotemporally precise interventions at clinically relevant tissue depths. In this Review, we examine the current optogenetics toolkit and the most notable preclinical and translational uses of optogenetics, and discuss future methodological and translational developments and bottlenecks.
Source Title: NATURE BIOMEDICAL ENGINEERING
URI: https://scholarbank.nus.edu.sg/handle/10635/227600
ISSN: 2157-846X
DOI: 10.1038/s41551-021-00829-3
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