Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jaip.2021.10.049
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dc.titleImpact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality
dc.contributor.authorRen, J
dc.contributor.authorPang, W
dc.contributor.authorLuo, Y
dc.contributor.authorCheng, D
dc.contributor.authorQiu, K
dc.contributor.authorRao, Y
dc.contributor.authorZheng, Y
dc.contributor.authorDong, Y
dc.contributor.authorPeng, J
dc.contributor.authorHu, Y
dc.contributor.authorYing, Z
dc.contributor.authorYu, H
dc.contributor.authorZeng, X
dc.contributor.authorZong, Z
dc.contributor.authorLiu, G
dc.contributor.authorWang, D
dc.contributor.authorWang, G
dc.contributor.authorZhang, W
dc.contributor.authorXu, W
dc.contributor.authorZhao, Y
dc.date.accessioned2022-06-29T05:18:36Z
dc.date.available2022-06-29T05:18:36Z
dc.date.issued2022-01-01
dc.identifier.citationRen, J, Pang, W, Luo, Y, Cheng, D, Qiu, K, Rao, Y, Zheng, Y, Dong, Y, Peng, J, Hu, Y, Ying, Z, Yu, H, Zeng, X, Zong, Z, Liu, G, Wang, D, Wang, G, Zhang, W, Xu, W, Zhao, Y (2022-01-01). Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality. Journal of Allergy and Clinical Immunology: In Practice 10 (1) : 124-133. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jaip.2021.10.049
dc.identifier.issn22132198
dc.identifier.issn22132201
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227544
dc.description.abstractBackground: It remains unclear if patients with allergic rhinitis (AR) and/or asthma are susceptible to corona virus disease 2019 (COVID-19) infection, severity, and mortality. Objective: To investigate the role of AR and/or asthma in COVID-19 infection, severity, and mortality, and assess whether long-term AR and/or asthma medications affected the outcomes of COVID-19. Methods: Demographic and clinical data of 70,557 adult participants completed SARS-CoV-2 testing between March 16 and December 31, 2020, in the UK Biobank were analyzed. The rates of COVID-19 infection, hospitalization, and mortality in relation to pre-existing AR and/or asthma were assessed based on adjusted generalized linear models. We further analyzed the impact of long-term AR and/or asthma medications on the risk of COVID-19 hospitalization and mortality. Results: Patients with AR of all ages had lower positive rates of SARS-CoV-2 tests (relative risk [RR]: 0.75, 95% confidence interval [CI]: 0.69-0.81, P < .001), with lower susceptibility in males (RR: 0.74, 95% CI: 0.65-0.85, P < .001) than females (RR: 0.8, 95% CI: 0.72-0.9, P < .001). However, similar effects of asthma against COVID-19 hospitalization were only major in participants aged <65 (RR: 0.93, 95% CI: 0.86-1, P = .044) instead of elderlies. In contrast, patients with asthma tested positively had higher risk of hospitalization (RR: 1.42, 95% CI: 1.32-1.54, P < .001). Neither AR nor asthma had an impact on COVID-19 mortality. None of conventional medications for AR or asthma, for example, antihistamines, corticosteroids, or β2 adrenoceptor agonists, showed association with COVID-19 infection or severity. Conclusion: AR (all ages) and asthma (aged <65) act as protective factors against COVID-19 infection, whereas asthma increases risk for COVID-19 hospitalization. None of the long-term medications had a significant association with infection, severity, and mortality of COVID-19 among patients with AR and/or asthma.
dc.publisherElsevier BV
dc.sourceElements
dc.subjectAllergic rhinitis
dc.subjectAsthma
dc.subjectCOVID-19
dc.subjectGlucocorticoids
dc.subjectLong-term medications
dc.subjectAdult
dc.subjectAsthma
dc.subjectCOVID-19
dc.subjectCOVID-19 Testing
dc.subjectFemale
dc.subjectHospitalization
dc.subjectHumans
dc.subjectMale
dc.subjectRhinitis, Allergic
dc.subjectSARS-CoV-2
dc.typeArticle
dc.date.updated2022-06-29T03:36:12Z
dc.contributor.departmentDEPT OF OTOLARYNGOLOGY
dc.description.doi10.1016/j.jaip.2021.10.049
dc.description.sourcetitleJournal of Allergy and Clinical Immunology: In Practice
dc.description.volume10
dc.description.issue1
dc.description.page124-133
dc.published.statePublished
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