Please use this identifier to cite or link to this item: https://doi.org/10.3389/fcell.2021.810842
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dc.titleMucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis
dc.contributor.authorPeng, Y
dc.contributor.authorWang, ZN
dc.contributor.authorXu, AR
dc.contributor.authorFang, ZF
dc.contributor.authorChen, SY
dc.contributor.authorHou, XT
dc.contributor.authorZhou, ZQ
dc.contributor.authorLin, HM
dc.contributor.authorXie, JX
dc.contributor.authorTang, XX
dc.contributor.authorWang, DY
dc.contributor.authorZhong, NS
dc.date.accessioned2022-06-29T04:58:18Z
dc.date.available2022-06-29T04:58:18Z
dc.date.issued2022-01-31
dc.identifier.citationPeng, Y, Wang, ZN, Xu, AR, Fang, ZF, Chen, SY, Hou, XT, Zhou, ZQ, Lin, HM, Xie, JX, Tang, XX, Wang, DY, Zhong, NS (2022-01-31). Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis. Frontiers in Cell and Developmental Biology 9 : 810842-. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2021.810842
dc.identifier.issn2296634X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227543
dc.description.abstractIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease attributed to the complex interplay of genetic and environmental risks. The muco-ciliary clearance (MCC) system plays a critical role in maintaining the conduit for air to and from the alveoli, but it remains poorly understood whether the MCC abnormalities in conducting airway are involved in IPF pathogenesis. In this study, we obtained the surgically resected bronchi and peripheral lung tissues from 31 IPF patients and 39 control subjects, and we sought to explore the morphologic characteristics of MCC in conducting airway by using immunostaining and scanning and transmission electron microscopy. In the submucosal regions of the bronchi, we found that the areas of mucus glands (MUC5B+) were significantly larger in IPF patients as compared with control subjects (p < 0.05). In the surface epithelium of three airway regions (bronchi, proximal bronchioles, and distal bronchioles), increased MUC5B and MUC5AC expression of secretory cells, decreased number of ciliated cells, and increased ciliary length were observed in IPF patients than control subjects (all p < 0.05). In addition, the mRNA expression levels of MUC5B were up-regulated in both the bronchi and peripheral lung of IPF patients than those of control subjects (p < 0.05), accompanied with 93.55% IPF subjects who had obvious MUC5B+ mucus plugs in alveolar regions. No MUC5B rs35705950 single-nucleotide polymorphism allele was detected in both IPF patients and control subjects. Our study shows that mucus hypersecretion and ciliary impairment in conducting airway are major causes of mucus plugs in alveolar regions and may be closely related to the alveolar injuries in IPF patients.
dc.publisherFrontiers Media SA
dc.sourceElements
dc.subjectMUC5B
dc.subjectconducting airway mucosa
dc.subjectidiopathic pulmonary fibrosis
dc.subjectmuco-ciliary clearance
dc.subjectmucus plugs
dc.typeArticle
dc.date.updated2022-06-29T03:34:07Z
dc.contributor.departmentDEPT OF OTOLARYNGOLOGY
dc.description.doi10.3389/fcell.2021.810842
dc.description.sourcetitleFrontiers in Cell and Developmental Biology
dc.description.volume9
dc.description.page810842-
dc.published.statePublished
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